Towards a new methodology of studying flints, by using GIS and a georeferenced database in the South of France

International audience; Towards a new methodology of studying flints, by using GIS and a georeferenced database in the South of France

Belief elicitation with multiple point predictions

Abstract We propose a simple, incentive compatible procedure based on binarized linear scoring rules to elicit beliefs about real-valued outcomes - multiple point predictions. Simultaneously eliciting multiple point predictions with linear incentives reveals the subjective probability distribution without pre-defined intervals or probabilistic statements. We show that the approach is theoretically as robust as existing methods, while adapting flexibly to different beliefs. In a laboratory experiment, we compare our procedure to the standard approach of eliciting discrete probabilities on pre-defined intervals. We find that elicitation with multiple point predictions is faster, perceived as …

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

Les formations à silex dans le Sud de la France : Élaboration en multipartenariat d’une base de données géoréférencées, premiers résultats.

A georeferenced database of the main flint-bearing formations of Southern France is currently being finalised. It offers a toolto all prehistorians that is essential for the development of studies regarding raw material circulation and selection criteria. This database results from the collaborative work of various actors involved in the optimisation of flint source determination. It groups together the results of their surveys — whether these are systematic or targeted — carried out in six regions (Aquitaine, Auvergne, Languedoc-Roussillon, Midi-Pyrénées, Provence-Alpes-Côte d’Azur, Rhône-Alpes). This database also incorporates recent studies on registering the properties of palaeoenvironm…

Rational Design of Thermoresponsive Microgel Templates with Polydopamine Surface Coating for Microtissue Applications.

Functional microgels provide a versatile basis for synthetic in vitro platforms as alternatives to animal experiments. The tuning of the physical, chemical, and biological properties of synthetic microgels can be achieved by blending suitable polymers and formulating them such to reflect the heterogenous and complex nature of biological tissues. Based on this premise, this paper introduces the development of volume-switchable core-shell microgels as 3D templates to enable cell growth for microtissue applications, using a systematic approach to tune the microgel properties based on a deep conceptual and practical understanding. Microscopic microgel design, such as the tailoring of the microg…

A map and a database for flint bearing formations in Southern France: a tool for Petroarchaeology

Une carte et une base de données pour les formations à silex dans le Sud de la France.

Programme et résumés, page 139; Une carte est en cours de réalisation pour figurer les principales formations contenant des silex dans le Sud de la France. Elle est le fruit d'une collaboration entre des acteurs impliqués dans la problématique de caractérisation de la provenance des silex. Elle regroupe les résultats de leurs prospections systématiques ou ciblées dans cinq régions (Auvergne, Rhône-Alpes, Provence Alpes Côte-d'Azur, Aquitaine, Midi-Pyrénées). Elle intègre le dépouillement d'un nombre considérable de documents : - 529 cartes géologiques au 1/50 000 et leurs notices ; - Plus de 200 fiches issues de la base de données du sous-sol BSS du BRGM, qui permettent de visualiser des lo…