Myc Promoter-Binding Protein-1 (MBP-1) transcriptionally represses ERBB2 gene, and identifies new subtypes of ERBB2 negative breast tumors

Nuclear Myc Promoter-Binding Protein-1 (MBP-1) Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma

Autism Spectrum Disorders: From Candidate Genes to Candidate Ontology Terms

Genetic heterogeneity for a multifactorial disease such as autism would imply that any two patients are unlikely to share the same susceptibility loci. Since different susceptibility loci may affect the same function and since functions may be considered at different levels of analysis, the following question arises: at what phenotypic levels is convergence attained by different genes in autism ? This is an important question to answer in order to shed light on subcellular, cellular or multicellular structures and functions possibly involved in the pathogenesis of autism. Among the various attempts made to answer this question it is worth mentioning the use of the best available genetic inf…

Nuclear myc promoter-binding protein-1 (MBP-1) expression is a prognostic factor in invasive ductal breast carcinoma

Insulators are DNA elements that block the extension of a condensed chromatin domain into a transcriptionally active region or prevent the interaction of a distal enhancer with a promoter when placed between the two. Human c-Myc and Pvt-1 genes map close each other and are separated by an intergenic region rich of DNAseI hypersensitivity sites. Starting from the observation that PVT1 expression is restricted to a low number of normal tissues compared to the wide distribution of c-Myc mRNA we focus our studies on the function and structure of the regions surrounding the DHs present between the two genes. Stable and transient transfection, indicate that one of the regions (HB-2.8) has enhance…