0000000001287418

AUTHOR

Marta Giussani

0000-0002-6606-2090

showing 1 related works from this author

Surveillance of spontaneous breast cancer metastasis by TRAIL-expressing CD34⁺ cells in a xenograft model

2012

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), delivered as a membrane-bound molecule expressed on the surface of adenovirus-transduced CD34+ cells (CD34-TRAIL+), was analyzed for its apoptotic activity in vitro on 12 breast cancer cell lines representing estrogen receptor-positive, HER2+ and triple-negative (TN) subtypes and for its effect on tumor growth, vascularization, necrosis, and lung metastasis incidence in NOD/SCID mice xenografted with the TN breast cancer line MDA-MB-231. Mesenchymal TN cell lines, which are the richest in putative tumor stem cells among the different breast cancer cell subtypes, were the most susceptible to apoptosis induced by CD34-TRAIL+ cel…

PathologyCancer ResearchCD34Antigens CD34ApoptosisMice SCIDMetastasisMetastasisTNF-Related Apoptosis-Inducing LigandMicePreclinical StudyMice Inbred NODNeoplasm Metastasisskin and connective tissue diseasesHeterologousTumorbiologyCell DeathCancer stem cellsTumor BurdenOncologyNeoplastic Stem CellsTumor necrosis factor alphaFemalemedicine.medical_specialtyTRAIL BREAST CANCERTransplantation HeterologousBreast NeoplasmsSCIDCell LineTriple-negative breast cancerCancer stem cellCell Line TumormedicineAnimalsHumansAntigensTransplantationCD44Mesenchymal stem cellmedicine.diseaseApoptosisCell culturebiology.proteinCancer researchInbred NODCD34Settore MED/36 - Diagnostica Per Immagini E RadioterapiaAnimals; Antigens CD34; Apoptosis; Breast Neoplasms; Cell Death; Cell Line Tumor; Female; Humans; Mice; Mice Inbred NOD; Mice SCID; Neoplasm Metastasis; Neoplastic Stem Cells; TNF-Related Apoptosis-Inducing Ligand; Transplantation Heterologous; Tumor BurdenmTRAIL
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