0000000001299339

AUTHOR

D. Schultz

showing 5 related works from this author

C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids

1991

Using a monoclonal antibody directed against the C-chain of human C1q, we detected C1q-bearing immune complexes (IC) in sera and synovial fluids of rheumatoid arthritis (RA) patients. In a sandwich-ELISA, C1q-bearing IC were captured by the solid-phase monoclonal antibody and then detected with peroxidase-labeled F(ab')2-antibodies to either human IgG or IgM. The results of this assay were compared to an ELISA-modification of the C1q-solid-phase binding assay (C1q-SPBA). C1q-bearing IC were detected in 81.1% of RA-sera and the 65.2% of RA-synovial fluids. IgG as well as IgM was present in 72.6% of the sera and 70% of the synovial fluids which were positive in both assays. Most RA sera that …

medicine.drug_classImmunologyEnzyme-Linked Immunosorbent Assaychemical and pharmacologic phenomenaAntigen-Antibody ComplexMonoclonal antibodyComplement Hemolytic Activity AssayArthritis RheumatoidImmunoglobulin Fab FragmentsClassical complement pathwayImmune systemRheumatologyimmune system diseasesOsteoarthritisSynovial FluidmedicineHumansImmunology and AllergySynovial fluidskin and connective tissue diseasesbiologybusiness.industryComplement C1qAntibodies Monoclonalmedicine.diseaseImmune complexImmunoglobulin MImmunoglobulin GRheumatoid arthritisMonoclonalImmunologybiology.proteinAntibodybusinessRheumatology International
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CCDC 688687: Experimental Crystal Structure Determination

2009

Related Article: P.Mal, D.Schultz, K.Beyeh, K.Rissanen, J.R.Nitschke|2008|Angew.Chem.,Int.Ed.|47|8297|doi:10.1002/anie.200803066

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatestetrakis(Tetramethylammonium) hexakis(mu~2~-NN'-bis(2-pyridylformyl)-44'-diaminobiphenyl-22'-disulfonate-NN'N''N''')-tetra-iron(ii) acetone clathrate hydrate
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CCDC 664077: Experimental Crystal Structure Determination

2009

Related Article: D.Schultz, F.Biaso, A.R.M.Shahi, M.Geoffroy, K.Rissanen, L.Gagliardi, C.J.Cramer, J.R.Nitschke|2008|Chem.-Eur.J.|14|7180|doi:10.1002/chem.200800503

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu~4~-NN'-bis((9-(2-(hydroxymethoxy)ethyliminomethyl)-110-phenanthrolin-2-yl)methylene)-12-phenylenediamine)-tetra-copper(i) tetraperchlorate hydrateExperimental 3D Coordinates
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CCDC 875091: Experimental Crystal Structure Determination

2012

Related Article: J.-F.Ayme, J.E.Beves, D.A.Leigh, R.T.McBurney, K.Rissanen, D.Schultz|2012|J.Am.Chem.Soc.|134|9488|doi:10.1021/ja303355v

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterspentakis(mu~3~-55'-bis(2-(6-(((24-Dimethoxybenzyl)imino)methyl)pyridin-3-yl)ethyl)-22'-bipyridine)-penta-iron(ii) chloride clathrate nonakis(hexafluorophosphate) acetonitrile unknown solvateExperimental 3D Coordinates
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CCDC 845599: Experimental Crystal Structure Determination

2012

Related Article: J.-F.Ayme, J.E.Beves, D.A.Leigh, R.T.McBurney, K.Rissanen, D.Schultz|2012|J.Am.Chem.Soc.|134|9488|doi:10.1021/ja303355v

Space GroupCrystallographyCrystal SystemCrystal Structure(mu~5~-7162736475667768796-Deca-aza-10133033505370739093-deca-oxa-1182238425862788298(25)252125414561658185(52)-icosapyridinacyclohectaphane-6162636465666768696-deca-ene)-penta-iron(ii) chloride clathrate nonakis(hexafluorophosphate) acetonitrile unknown solvate pentahydrateCell ParametersExperimental 3D Coordinates
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