0000000001299339
AUTHOR
D. Schultz
C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids
Using a monoclonal antibody directed against the C-chain of human C1q, we detected C1q-bearing immune complexes (IC) in sera and synovial fluids of rheumatoid arthritis (RA) patients. In a sandwich-ELISA, C1q-bearing IC were captured by the solid-phase monoclonal antibody and then detected with peroxidase-labeled F(ab')2-antibodies to either human IgG or IgM. The results of this assay were compared to an ELISA-modification of the C1q-solid-phase binding assay (C1q-SPBA). C1q-bearing IC were detected in 81.1% of RA-sera and the 65.2% of RA-synovial fluids. IgG as well as IgM was present in 72.6% of the sera and 70% of the synovial fluids which were positive in both assays. Most RA sera that …
CCDC 688687: Experimental Crystal Structure Determination
Related Article: P.Mal, D.Schultz, K.Beyeh, K.Rissanen, J.R.Nitschke|2008|Angew.Chem.,Int.Ed.|47|8297|doi:10.1002/anie.200803066
CCDC 664077: Experimental Crystal Structure Determination
Related Article: D.Schultz, F.Biaso, A.R.M.Shahi, M.Geoffroy, K.Rissanen, L.Gagliardi, C.J.Cramer, J.R.Nitschke|2008|Chem.-Eur.J.|14|7180|doi:10.1002/chem.200800503
CCDC 875091: Experimental Crystal Structure Determination
Related Article: J.-F.Ayme, J.E.Beves, D.A.Leigh, R.T.McBurney, K.Rissanen, D.Schultz|2012|J.Am.Chem.Soc.|134|9488|doi:10.1021/ja303355v
CCDC 845599: Experimental Crystal Structure Determination
Related Article: J.-F.Ayme, J.E.Beves, D.A.Leigh, R.T.McBurney, K.Rissanen, D.Schultz|2012|J.Am.Chem.Soc.|134|9488|doi:10.1021/ja303355v