Author: M. Meli

0000000001300708

AUTHOR

M. Meli

Farmaci inibitori delle topoisomerasi

Le DNA-topoisomerasi, identificate per la prima volta nel 1971, sono enzimi chiave nella regolazione della struttura topologica del DNA.

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PHENOLOGICAL AND MORPHOLOGICAL STUDIES OF PISTACIA TEREBINTHUS L. GENOTYPES NATIVE OF BULGARIA WITH DIFFERENT ASSET OF TREE SEXUALITY

The genus Pistacia is a dioecious species staminate and pistillate inflorescences born on different trees and are wind pollinated. In pistachio orchards, female and male flowering periods are often not synchronized. In fact, male trees spread their pollen before the flowers of female trees become receptive. Pollination is commonly devoted to spontaneous males of P. terebinthus. In this research authors refer to the results obtained observing the phenology of the blooming period of monoicous genotypes of P. terebinthus discovered in the Rhodope Mountains (Bulgaria). In some selected trees phenological stages have been observed in situ. The blooming date is influenced by local environmental c…

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Body Mass Index and Weight Gain in Pregnant Women With HIV: A National Study in Italy.

Although most of the women (69.4%) had a normal BMI at start of pregnancy, only 37% had an adequate weight gain during pregnancy. Inadequate body weight gain was more common (44.8%) than excessive weight gain (18.2%), but 40% of overweight women and 50% of obese women had an excessive weight gain in pregnancy, with about 9% of the women in these categories gaining >18 kg during pregnancy (Table 1). Only 1.9% of the women had a vaginal delivery; elective and nonelective cesarean deliveries accounted for 81.3% and 16.7% of deliveries, respectively. Compared to underweight/normal women, overweight/obese women had similar occurrences of preterm delivery (23.4% vs 22.7%, P = .871), significantly…

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Resistance to Gemcitabine in a Lymphoma Cell Line Resistant to Fas-mediated Apoptosis

BACKGROUND: The T-cell lymphoma cell line HuT78B1, selected for resistance to Fas-mediated apoptosis, resulted unexpectedly resistant to the apoptotic and cytotoxic effects of gemcitabine (dFdC). We investigated whether this resistance was due to the impairment of the Fas/Fas-ligand (FasL) system. MATERIALS AND METHODS: dFdC effects were studied in HuT78B1 and in the parental Fas-sensitive HuT78 cells exposed to inhibitors of the Fas/FasL system. RESULTS: FasL- and Fas-blocking antibodies did not interfere with dFdC-induced apoptosis in HuT78 cells, whereas inhibitors of caspase-8, -9, -1 or -3 had partial inhibitory effects. Notably, in HuT78B1 cells there was a markedly reduced dFdC accum…

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5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma: A multicentric randomized study

Biochemical modulation is one of the most interesting fields in cancer chemotherapy. Interferon-alpha (IFNalpha) is a cytokine that is able to influence the pharmacodynamics of 5-fluorouracil (5FU) through a number of mechanisms. With the aim of confirming some data emerging from the literature, we initiated a multicentric randomized study comparing the combination of 5FU and IFNalpha-2a with 5FU alone in the treatment of advanced or metastatic colon cancer. A group of 205 colon cancer patients (104 in the 5FU arm and 101 in the 5FU + IFNapha-2a arm) were included in the final intention-to-treat analysis. Rectal cancers were not considered eligible. All patients had measurable disease, were…

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CCDC 204502: Experimental Crystal Structure Determination

Related Article: A.Volonterio, S.Bellosta, F.Bravin, M.C.Bellucci, L.Bruche, G.Colombo, L.Malpezzi, S.Mazzini, S.V.Meille, M.Meli, C.R.de Arellano, M.Zanda|2003|Chem.-Eur.J.|9|4510|doi:10.1002/chem.200304881

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CCDC 204503: Experimental Crystal Structure Determination

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CCDC 204501: Experimental Crystal Structure Determination

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