0000000001301954
AUTHOR
Javier Torres
Domino Synthesis of 3-Alkyliden-2,3-Dihydro-4-Quinolones
Organocatalytic Enantioselective Intramolecular (Hetero)Michael Additions in Desymmetrization Processes
Organocatalytic Enantioselective Friedel‐Crafts Alkylation Reactions of Pyrroles
Highly convergent total synthesis of (+)-anaferine and (−)-dihydrocuscohygrine
A unified and highly convergent total synthesis of anaferine and dihydrocuscohygrine alkaloids has been devised, taking advantage of the dual role of N-sulfinyl amines as nucleophilic nitrogen sources and chiral auxiliaries. A bidirectional cross metathesis reaction followed by a double intramolecular aza-Michael reaction led us to create the whole skeleton of the natural products in a very simple manner.
New sulfonamide complexes with essential metal ions [Cu (II), Co (II), Ni (II) and Zn (II)]. Effect of the geometry and the metal ion on DNA binding and nuclease activity. BSA protein interaction.
Abstract Mixed divalent Cu, Co, Ni and Zn complexes containing the new sulfonamide ligand N–(2–(pyridin–2–yl)ethyl)quinoline–8–sulfonamide (HQSEP) were prepared and characterized by physico-chemical techniques. The tetracoordinate [Cu(QSEP)X] [X = Br (1), Cl (2)] compounds present a seesaw geometry (τ4 = 0.56 (1) and 0.50 (2)). The Cu(II) in the [Cu(QSEP)(NO3)(MeOH)] (3) complex is five coordinate with a slightly distorted SP geometry (τ = 0.11). The [M(QSEP)(benz)] [M = Cu(II) (4), Ni(II) (5), Co(II) (6) and Zn(II) (7); benz = benzoate] compounds are configurationally isotypic. The coordination geometries of the M(II) ions can be best described as distorted SP (τ = 0.29, 0.15, 0.34 and 0.1…
Double asymmetric intramolecular aza-Michael reaction: a convenient strategy for the synthesis of quinolizidine alkaloids.
A new methodology to access the quinolizidine skeleton in an asymmetric fashion was devised. It involves two consecutive intramolecular aza-Michael reactions of sulfinyl amines bearing a bis-enone moiety, in turn generated by a monodirectional cross metathesis reaction. The sequence, which takes place with excellent yields and diastereocontrol, was applied to the total synthesis of alkaloids lasubine I and myrtine.
Recurrent wheezing during the first 3 years of life in a birth cohort of moderate-to-late preterm infants.
Background Data addressing short- and long-term respiratory morbidity in moderate-late preterm infants are limited. We aim to determine the incidence of recurrent wheezing and associated risk and protective factors in these infants during the first 3 years of life. Methods Prospective, multicenter birth cohort study of infants born at 32+0 to 35+0 weeks' gestation and followed for 3 years to assess the incidence of physician-diagnosed recurrent wheezing. Allergen sensitization and pulmonary function were also studied. We used multivariate mixed-effects models to identify risk factors associated with recurrent wheezing. Results A total of 977 preterm infants were enrolled. Rates of recurrent…
Asymmetric Vinylogous Mannich-Type Addition of α,α-Dicyanoalkenes to α-Fluoroalkyl Sulfinyl Imines
Abstract. The asymmetric vinylogous Mannich reaction (AVMR) of alfa,alfa-dicyanoalkenes with alfa-fluoroalkyl sulfinyl imines has been successfully accomplished. This transformation is unprecedented with fluorinated imines at the same time as the use of dicyanoalkenes in AVMR has been scarcely reported. Several fluorinated sulfinyl imines are compatible with the process, which gaves access to a family of chiral fluorinated amines with excellent level of stereocontrol. Interestingly, the selectivity found in our protocol is reverse to that encountered in analogous AVMR previously reported. Additionally, the synthetic applicability of the addition products has been exemplified with several tr…
Organocatalytic enantioselective synthesis of 2,5,5-trisubstituted piperidines bearing a quaternary stereocenter. Vinyl sulfonamide as a new amine protecting group
An organocatalytic desymmetrizing intramolecular aza-Michael reaction with vinyl sulfonamides as nucleophilic nitrogen source has been devised for the synthesis of a new family of 2,5,5-trisubstituted piperidines bearing a quaternary sterocenter. The process takes place with excellent levels of enantioselectivity and moderate to good diastereoselectivity. The vinyl sulfonamide moiety can be removed by means of an ozonolysis reaction.
Organocatalytic enantioselective synthesis of trifluoromethyl-containing tetralin derivatives by sequential (hetero)Michael reaction–intramolecular nitrone cycloaddition
The enantioselective synthesis of tetralin derivatives bearing a trifluoromethylated all‐carbon quaternary stereocenter has been accomplished through a synthetic sequence comprising an organocatalytic β‐functionalization of ortho‐1‐trifluoromethylvinyl‐(hetero)aromatic conjugated aldehydes followed by the intramolecular nitrone 1,3‐cycloaddition reaction (INCR). Both nitromethane and N‐Cbz‐hydroxylamine were employed as nucleophiles in the initial organocatalytic conjugate addition step, which provided the chiral information required for the subsequent diastereoselective INCR. Although diastereoselectivity was moderate, good yields and enantioselectivities were, in general, obtained. Intere…
CCDC 1564495: Experimental Crystal Structure Determination
Related Article: Fernando Rabasa-Alcañiz, Javier Torres, María Sánchez-Roselló, Tomás Tejero, Pedro Merino, Santos Fustero, Carlos del Pozo|2017|Adv.Synth.Catal.|359|3752|doi:10.1002/adsc.201700975
CCDC 1578271: Experimental Crystal Structure Determination
Related Article: Álvaro Sanz-Vidal, Javier Torres, Vadim A. Soloshonok, Yi Zhu, Jianlin Han, Santos Fustero, Carlos del Pozo|2018|Adv.Synth.Catal.|360|366|doi:10.1002/adsc.201701284
CCDC 1915276: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1915272: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1915273: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1919952: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1915275: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1915274: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1564490: Experimental Crystal Structure Determination
Related Article: Fernando Rabasa-Alcañiz, Javier Torres, María Sánchez-Roselló, Tomás Tejero, Pedro Merino, Santos Fustero, Carlos del Pozo|2017|Adv.Synth.Catal.|359|3752|doi:10.1002/adsc.201700975
CCDC 1578275: Experimental Crystal Structure Determination
Related Article: Álvaro Sanz-Vidal, Javier Torres, Vadim A. Soloshonok, Yi Zhu, Jianlin Han, Santos Fustero, Carlos del Pozo|2018|Adv.Synth.Catal.|360|366|doi:10.1002/adsc.201701284
CCDC 1919951: Experimental Crystal Structure Determination
Related Article: Tamara Tŏpala, Alejandro Pascual–Álvarez, M. Ángeles Moldes–Tolosa, Andreea Bodoki, Alfonso Castiñeiras, Javier Torres, Carlos del Pozo, Joaquín Borrás, Gloria Alzuet–Piña|2020|J.Inorg.Biochem.|202|110823|doi:10.1016/j.jinorgbio.2019.110823
CCDC 1891128: Experimental Crystal Structure Determination
Related Article: Marcos Escolano, Marta Guerola, Javier Torres, Daniel Gaviña, Gloria Alzuet-Piña, María Sánchez-Rosello, Carlos del Pozo|2020|Chem.Commun.|56|1425|doi:10.1039/C9CC09113K
CCDC 1578276: Experimental Crystal Structure Determination
Related Article: Álvaro Sanz-Vidal, Javier Torres, Vadim A. Soloshonok, Yi Zhu, Jianlin Han, Santos Fustero, Carlos del Pozo|2018|Adv.Synth.Catal.|360|366|doi:10.1002/adsc.201701284