0000000001302124

AUTHOR

Joachim Rheinheimer

showing 8 related works from this author

Total Synthesis of the Antifungal Natural Product Mollisin

2013

Mollisin, a bioactive polyketide secondary metabolite of the fungus Mollisia caesia, was synthesized in nine linear steps from commercially available 2,6-dimethyl-γ-pyrone. A key transformation in this first total synthesis of mollisin was the ipso substitution of an arylstannane, which permitted the otherwise cumbersome introduction of the characteristic dichloroacetyl moiety. The fungal fungicide was obtained in an overall yield of 9 %.

Natural productbiologyStereochemistryOrganic ChemistryTotal synthesisSecondary metabolitebiology.organism_classificationFungicideAcylationMollisiachemistry.chemical_compoundPolyketidechemistrymedicineOrganic chemistryMoietyPhysical and Theoretical Chemistrymedicine.drugEuropean Journal of Organic Chemistry
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Coumarin derivatives from Pedilanthus tithymaloides as inhibitors of conidial germination in Magnaporthe oryzae

2012

In a screening for inhibitors of infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae, a series of 10 coumarin derivatives were isolated from Pedilanthus tithymaloides (Euphorbiaceae). Seven of these compounds turned out to be known while three represent previously unreported natural products. Their structures were established on the basis of spectroscopic data and X-ray crystallography. Nine out of 10 coumarin derivatives were found to inhibit conidial germination in the phytopathogenic fungus at low concentrations.

biologyPedilanthus tithymaloidesChemistryOrganic ChemistryEuphorbiaceaeFungusbiology.organism_classificationCoumarinBiochemistryMagnaporthe oryzaechemistry.chemical_compoundBiochemistryGerminationDrug Discoveryheterocyclic compoundsVolume concentrationTetrahedron Letters
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ChemInform Abstract: Total Synthesis of the Antifungal Natural Product Mollisin.

2014

The title compound is synthesized in nine steps from commercially available 2,6-dimethyl-γ-pyrone in an overall yield of 9%.

Antifungalchemistry.chemical_compoundNatural productchemistrymedicine.drug_classYield (chemistry)medicineOrganic chemistryTotal synthesisGeneral MedicineChemInform
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CCDC 861603: Experimental Crystal Structure Determination

2016

Related Article: Louis P. Sandjo, Andrew J. Foster, Joachim Rheinheimer, Heidrun Anke, Till Opatz, Eckhard Thines|2012|Tetrahedron Lett.|53|2153|doi:10.1016/j.tetlet.2012.02.056

Space GroupCrystallographyCrystal System57-dihydroxy-8-(3-methylbutanoyl)-4-phenyl-2H-chromen-2-one chloroform solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 945345: Experimental Crystal Structure Determination

2013

Related Article: Sonja Schwolow, Horst Kunz, Joachim Rheinheimer, Till Opatz|2013|Eur.J.Org.Chem.|2013|6519|doi:10.1002/ejoc.201301088

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters8-(Dichloroacetyl)-5-hydroxy-27-dimethyl-14-naphthoquinoneExperimental 3D Coordinates
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CCDC 945347: Experimental Crystal Structure Determination

2013

Related Article: Sonja Schwolow, Horst Kunz, Joachim Rheinheimer, Till Opatz|2013|Eur.J.Org.Chem.|2013|6519|doi:10.1002/ejoc.201301088

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters26-Dihydroxyhepta-25-dien-4-oneExperimental 3D Coordinates
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CCDC 945348: Experimental Crystal Structure Determination

2013

Related Article: Sonja Schwolow, Horst Kunz, Joachim Rheinheimer, Till Opatz|2013|Eur.J.Org.Chem.|2013|6519|doi:10.1002/ejoc.201301088

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters22-Dichloro-1-(45-dimethoxy-27-dimethylnaphthalen-1-yl)ethanoneExperimental 3D Coordinates
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CCDC 945346: Experimental Crystal Structure Determination

2013

Related Article: Sonja Schwolow, Horst Kunz, Joachim Rheinheimer, Till Opatz|2013|Eur.J.Org.Chem.|2013|6519|doi:10.1002/ejoc.201301088

Space GroupCrystallographyCrystal System8-(Dichloroacetyl)-5-methoxy-27-dimethyl-14-naphthoquinoneCrystal StructureCell ParametersExperimental 3D Coordinates
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