0000000001302996
AUTHOR
Gang Xie
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
A triple-bridged azido-Cu(II) chain compound fine-tuned by mixed carboxylate/ethanol linkers displays slow-relaxation and ferromagnetic order: synthesis, crystal structure, magnetic properties and DFT calculations.
A new azido-Cu(II) compound, [Cu(4-fba)(N3)(C2H5OH)] (4-fba = 4-fluorobenzoic acid) (1), has been synthesized and characterized. The X-ray crystal structure analysis demonstrates that only one crystallographically independent Cu(II) ion in the asymmetric unit of 1 exhibits a stretched octahedral geometry in which two azido N atoms and two carboxylic O atoms locate in the equatorial square, while two ethanol O atoms occupy the apical positions, forming a 1D Cu(II) chain with an alternating triple-bridge of EO-azido, syn,syn-carboxylate, and μ2-ethanol. The title compound consists of ferromagnetically interacting ferromagnetic chains, which exhibit ferromagnetic order (Tc = 7.0 K). The strong…
Capping N‐Donor Ligands Modulate the Magnetic Dynamics of Dy III β‐Diketonate Single‐Ion Magnets with D 4 d Symmetry
A family of four mononuclear DyIII β-diketonate complexes with formulas [Dy(tmhd)3 (Br2 -bpy) (1), [Dy(tmhd)3 (Br-bpy)] (2), [Dy(tmhd)3 (dppz)] (3), and [Dy(tmhd)3 (mcdpq)] (4) (tmhd=2,2,6,6-tetramethyl-3,5-heptanedione, Br2 -bpy=5,5'-dibromo-2,2'-bipyridine, Br-bpy=5-bromo-2,2'-bipyridine, dppz=dipyrido [3,2-a:2',3'-c]phenazine, mcdpq=2-methoxyl-3-cyanodipyrido[3,2-f:2,3'-h]quinoxaline) were prepared by modifying the capping N-donor coligands. DyIII centers in these complexes feature an N2 O6 octacoordinate environment with distorted square-antiprismatic D4d symmetry. Magnetic investigations evidenced single-ion magnet behavior in all complexes with energy barriers Ueff of 42.10 (1), 61.47…
Modulating magnetic dynamics through tailoring the terminal ligands in Dy2 single-molecule magnets
Complexation of dysprosium(III) ions with a multidentate hydrazone ligand, N-[(E)-pyridin-2-ylmethylideneamino]pyridine-2-carboxamide (L), in the presence of different β-diketonate coligands, leads to the formation of two novel DyIII dimers, with formulas Dy2(BTFA)4(L)2 (1) and Dy2(TTA)4(L)2 (2) (BTFA = 3-benzoyl-1,1,1-trifluoroacetone and TTA = 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionate). They exhibit slightly different coordination geometries around DyIII centers and discrepant binuclear motifs – as a result of altering the β-diketonate coligands – which has an impact on the magnetic interactions between metal centers, the local tensor of anisotropy on each DyIII site and their relat…
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
Concise Chemistry Modulation of the SMM Behavior within a Family of Mononuclear Dy(III) Complexes.
By means of the facile chemistry, structural assembly, and transformation of four mononuclear Dy(III) complexes, Dy(bpad)3·CH3OH·H2O (1), Dy(bpad)2(H2O)2·NO3 (2), [Dy(bpad)2(tmhd)] (3), and [Dy(bpad)2(btfa)] (4) (Hbpad = N3-benzoylpyridine-2-carboxamidrazone, tmhd = 2,2,6,6-tetramethylheptane-3,5-dione, btfa = 3-benzoyl-1,1,1-trifluoroacetone), with distinct architectures and local symmetries were established. The disparity of the coordination geometries around the Dy(III) ion among these complexes impacts the strength of the crystal field and the local tensor of anisotropy ( D) of each Dy site and their relative orientations, therefore giving rise to diverse SIM behaviors with distinguishi…
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 77…
CCDC 1873718: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Jesús Ferrando-Soria, Yi-Quan Zhang, Gang Xie, Sanping Chen, Emilio Pardo|2018|Chem.-Eur.J.|25|3884|doi:10.1002/chem.201805608
CCDC 1845918: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Xiufang Ma, Weize Yuan, Peipei Cen, Yi-Quan Zhang, Jes��s Ferrando-Soria, Gang Xie, Sanping Chen, and Emilio Pardo|2018|Inorg.Chem.|57|14843|doi:10.1021/acs.inorgchem.8b02602
CCDC 1873720: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Jesús Ferrando-Soria, Yi-Quan Zhang, Gang Xie, Sanping Chen, Emilio Pardo|2018|Chem.-Eur.J.|25|3884|doi:10.1002/chem.201805608
CCDC 1845916: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Xiufang Ma, Weize Yuan, Peipei Cen, Yi-Quan Zhang, Jes��s Ferrando-Soria, Gang Xie, Sanping Chen, and Emilio Pardo|2018|Inorg.Chem.|57|14843|doi:10.1021/acs.inorgchem.8b02602
CCDC 1845917: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Xiufang Ma, Weize Yuan, Peipei Cen, Yi-Quan Zhang, Jes��s Ferrando-Soria, Gang Xie, Sanping Chen, and Emilio Pardo|2018|Inorg.Chem.|57|14843|doi:10.1021/acs.inorgchem.8b02602
CCDC 1875514: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Yi-Quan Zhang, Jesús Ferrando-Soria, Gang Xie, Sanping Chen, Emilio Pardo|2020|Dalton Trans.|49|808|doi:10.1039/C9DT03993G
CCDC 980967: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Sanping Chen, Thais Grancha, Emilio Pardo, Hongshan Ke, Bing Yin, Qing Wei, Gang Xie, Shengli Gao|2014|Dalton Trans.|43|15359|doi:10.1039/C4DT02195A
CCDC 1845915: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Xiufang Ma, Weize Yuan, Peipei Cen, Yi-Quan Zhang, Jes��s Ferrando-Soria, Gang Xie, Sanping Chen, and Emilio Pardo|2018|Inorg.Chem.|57|14843|doi:10.1021/acs.inorgchem.8b02602
CCDC 1873719: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Jesús Ferrando-Soria, Yi-Quan Zhang, Gang Xie, Sanping Chen, Emilio Pardo|2018|Chem.-Eur.J.|25|3884|doi:10.1002/chem.201805608
CCDC 1875515: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Yi-Quan Zhang, Jesús Ferrando-Soria, Gang Xie, Sanping Chen, Emilio Pardo|2020|Dalton Trans.|49|808|doi:10.1039/C9DT03993G
CCDC 1478583: Experimental Crystal Structure Determination
Related Article: Xiangyu Liu, Xiufang Ma, Weize Yuan, Peipei Cen, Yi-Quan Zhang, Jes��s Ferrando-Soria, Gang Xie, Sanping Chen, and Emilio Pardo|2018|Inorg.Chem.|57|14843|doi:10.1021/acs.inorgchem.8b02602
CCDC 1873721: Experimental Crystal Structure Determination
Related Article: Peipei Cen, Xiangyu Liu, Jesús Ferrando-Soria, Yi-Quan Zhang, Gang Xie, Sanping Chen, Emilio Pardo|2018|Chem.-Eur.J.|25|3884|doi:10.1002/chem.201805608