6533b7d3fe1ef96bd12615c4
RESEARCH PRODUCT
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
Massimo ZuinAntonio BenedettiPierluigi ToniuttoVincenzo PalmieriPeter K. GregersenCristina RigamontiChristopher I. AmosPaolo MuratoriBarbara CocoFrancesca BernuzziPiero Luigi AlmasioRenzo MontanariMaurizia Rossana BrunettoFabio MacciardiFabio MacciardiAndrea GalliPietro AndreoneCameron N. GhentYue LuLuca FabrisGideon M. HirschfieldMarzia MargottiMichael RansomIlaria BianchiAgostino ColliCarlo SelmiCarlo SelmiGiancarlo SpinziLory Saveria CrocèS. BrunoGang XieMario StrazzaboscoMario StrazzaboscoClaudio TiribelliXiangdong LiuGrazia Anna NiroE. Jenny HeathcoteRussell ShigetaKatherine A. SiminovitchElisabetta BorghesioNicola CaporasoM. Eric GershwinAndrew MasonMaria VinciMauro PoddaRobert P. MyersFabio MarraCleofe PriscoLorenzo MoriniRoman KosoyAlberto MattaliaMichael F. SeldinChun XuMaria Consiglia BragazziPiero PortincasaRoberta LazzariGiovanni CasellaSonia RossiMarco MarzioniSilvia ColomboDomenico AlvaroLuigi MuratoriSara LupoliCarlo FerrariAnnette LeeAnnarosa FloreaniYan LuFloriano RosinaAngelo AndriulliMassimo ColomboAntonio PicciottoKevork M. PeltekianAna LleoAna LleoAlessandro PisanoPietro Invernizzisubject
Liver CirrhosisOncologyCanadamedicine.medical_specialtyCirrhosisEuropean Continental Ancestry GroupLOCIPRIMARY BILIARY CIRRHOSIS; GENOME WIDE ASSOCIATION; LOCIGenome-wide association studyLocus (genetics)genetics Genome Genome-Wide Association Study Humans Interferon Regulatory Factors Liver CirrhosiBiologyBiliary Meta-Analysis as Topic Odds RatioWhite PeopleArticleGENOME WIDE ASSOCIATIONAlleles Canada European Continental Ancestry Groupprimary biliary cirrhosiPrimary biliary cirrhosisMeta-Analysis as TopicMED/12 - GASTROENTEROLOGIAIL12AInternal medicineOdds RatioGeneticsmedicineHumansAllelegenomeAlleles Canada European Continental Ancestry Group; genetics Genome Genome-Wide Association Study Humans Interferon Regulatory Factors Liver Cirrhosis; Biliary Meta-Analysis as Topic Odds RatioAllelesprimary biliary cirrhosis genome-wide meta-analysesGeneticsLiver Cirrhosis BiliaryBiliaryOdds ratiomedicine.diseasePrimary biliary cirrhosisInterferon Regulatory FactorsCohortGenome-Wide Association Studydescription
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-07-18 |