RAGE Mediates a Novel Proinflammatory Axis

S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathw…

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).

METAPHOR ANALYSIS OF TEACHERS’ ROLES IN THE LESS COMMONLY TAUGHT EUROPEAN LANGUAGES PROGRAMS IN CHINA

Teachers’ individual understanding of the roles in their own profession influences the construction of teacher-student and other work relationships. It is also an important indicator for language program managers to perceive the teaching and learning process. Metaphor analysis is an effective method to raise awareness and reflection of professional roles among teachers. This study employs the open-ended questionnaire to investigate the professional roles of the teachers in the Less Commonly Taught European Languages (LCTELs) programs in China. The framework provided by De Guerrero and Villamil’s research is adapted to design and conduct the questionnaire. The elicited metaphors are collecte…

Investigation of Latvian Language Program Management Models in Major Worldwide Universities