0000000001303272

AUTHOR

Ute Schepers

showing 6 related works from this author

Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

2014

The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.

Stereochemistrychemistry.chemical_elementCrystal structure010402 general chemistry01 natural sciencesMedicinal chemistryInorganic ChemistryHeLachemistry.chemical_compoundmedicinePhysical and Theoretical ChemistryCytotoxicityta116Cisplatinbiology010405 organic chemistryArylOrganic ChemistryNuclear magnetic resonance spectroscopybiology.organism_classification3. Good health0104 chemical scienceschemistryPlatinumCyclooctadienemedicine.drugOrganometallics
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CCDC 993792: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(cycloocta-15-diene)-dimesityl-platinum(ii)Experimental 3D Coordinates
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CCDC 993789: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-ethylcycloocta-15-diene)-diiodo-platinum(ii)Experimental 3D Coordinates
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CCDC 993790: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdiiodo-(1-phenylcycloocta-15-diene)-platinum(ii)Experimental 3D Coordinates
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CCDC 993788: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscis-dichloro-(cycloocta-15-diene)-platinum(ii)Experimental 3D Coordinates
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CCDC 993791: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-methylcycloocta-15-diene)-diphenyl-platinum(ii)Experimental 3D Coordinates
researchProduct