0000000001305310

AUTHOR

Bastian Greshake

showing 11 related works from this author

openSNP–A Crowdsourced Web Resource for Personal Genomics

2014

Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genet…

GenotypeScienceInformation Storage and RetrievalBiological Data ManagementGenome-wide association studyGenomicsBiologySocial and Behavioral SciencesPolymorphism Single NucleotideFormal CommentGenomic MedicineGenome Analysis Toolsddc:570Genetic variationGenome-Wide Association StudiesGenome DatabasesGeneticsmedicineHumansGenetic TestingPrecision MedicineBiologyGenetic Association StudiesInformation ScienceGenetic testingGenetic associationClinical GeneticsGeneticsInternetMultidisciplinarymedicine.diagnostic_testInformation DisseminationQPersonalized MedicineRComputational BiologyHuman GeneticsGenomicsGeneticistData scienceOpen dataPhenotypeGenetics of DiseaseMedicineCrowdsourcingSoftwareResearch ArticleGenome-Wide Association StudyPersonal genomicsPLoS ONE
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Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

AbstractBackgroundLife history traits like developmental time, age and size at maturity are directly related to fitness in all organisms and play a major role in adaptive evolution and speciation processes. Comparative genomic or transcriptomic approaches to identify positively selected genes involved in species divergence can help to generate hypotheses on the driving forces behind speciation. Here we use a bottom-up approach to investigate this hypothesis by comparative analysis of orthologous transcripts of four closely related EuropeanRadixspecies.ResultsSnails of the genusRadixoccupy species specific distribution ranges with distinct climatic niches, indicating a potential for natural …

ClimateSnailsZoologyLife history theorySpecies SpecificityPhylogeneticsAnimalsRNA-SeqAdaptationSelection GeneticTranscriptomicsEcosystemPhylogenyEcology Evolution Behavior and SystematicsEcological nicheMollusksNatural selectionbiologyPhylogenetic treeGene Expression ProfilingReproductive isolationbiology.organism_classificationReproductive isolationBiological EvolutionReproductive isolation ; RNA-Seq ; Transcriptomics ; Adaptive sequence evolution ; Positive selection ; Mollusks ; AdaptationPositive selectionEuropeGene Expression RegulationEvolutionary biologyAdaptationAdaptive sequence evolutionResearch ArticleRadix (gastropod)BMC Evolutionary Biology
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Additional file 6: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Snail collection sites. (PDF 330 kb)

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Additional file 3: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Results and figure for the climate niche divergence PCA. (PDF 14 kb)

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Additional file 1: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Results of the a) sequencing effort and b) assembly statistics. (PDF 257 kb)

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Additional file 2: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Phylogenetic inference on species relationships. (PDF 255 kb)

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Additional file 5: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Results enrichment analyses. (XLSX 11 kb)

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Additional file 4: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Selected genes with annotations. (XLSX 35 kb)

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Additional file 7: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Radix mt-genome primers. (XLS 36 kb)

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Additional file 8: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Annotations and evolutionary models of the clusters used for phylogenetic inference. (XLSX 10 kb)

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Data from: Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix

2015

Background: Life history traits like developmental time, age and size at maturity are directly related to fitness in all organisms and play a major role in adaptive evolution and speciation processes. Comparative genomic or transcriptomic approaches to identify positively selected genes involved in species divergence can help to generate hypotheses on the driving forces behind speciation. Here we use a bottom-up approach to investigate this hypothesis by comparative analysis of orthologous transcripts of four closely related European Radix species. Results: Snails of the genus Radix occupy species specific distribution ranges with distinct climatic niches, indicating a potential for natural…

medicine and health careRadixpositive selectionRadix balthicaMedicinemollusksAdaptive sequence evolutionLife sciences
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