0000000001305719
AUTHOR
Cordian Beyer
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed
BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
Several lines of evidence indicate that remyelination represents one of the most effective mechanisms to achieve axonal protection. For reasons that are not yet understood, this process is often incomplete or fails in multiple sclerosis (MS). Activated astrocytes appear to be able to boost or inhibit endogenous repair processes. A better understanding of remyelination in MS and possible reasons for its failure is needed. Using the well-established toxic demyelination cuprizone model, we created lesions with either robust or impaired endogenous remyelination capacity. Lesions were analyzed for mRNA expression levels by Affymetrix GeneChip® arrays. One finding was the predominance of immune a…
CCDC 1846187: Experimental Crystal Structure Determination
Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523
CCDC 1846185: Experimental Crystal Structure Determination
Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523
CCDC 1846186: Experimental Crystal Structure Determination
Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523