Effects of phenols of extra vergin olive oil on Hl60 cell lines sensitive and resistant to anthracycline

Induction of differentiation by phenols crude extract of extravirgin olive oil on tumor cell lines sensitive and resistatnt to antitumor agents

Modificazioni di alcuni parametri immunitari in un gruppo di sportivi amatoriali praticanti maratona ed ultramaratona

The function of the Immune System is that to distinguish "self" from "not-self". The immune answer includes a "specific" phase and a "not specific" phase. The phagocytes, as macrophages, granulocytes and natural killer cells constitute a successful defense against viral infections and some types of cancer. The Specific System is made by Ly-T and Ly-B: the first are divided into Ly-T helper and Ly-T suppressor; the second differentiates into Plasmacytes. The IgA, present into the nasal mucosa and the bronchial secretion, represent an early defense, able to block virus penetration. The data of the research show that a moderate exercise can limit the immune depression. It has been supposed tha…

Resistance to Gemcitabine in a Lymphoma Cell Line Resistant to Fas-mediated Apoptosis

BACKGROUND: The T-cell lymphoma cell line HuT78B1, selected for resistance to Fas-mediated apoptosis, resulted unexpectedly resistant to the apoptotic and cytotoxic effects of gemcitabine (dFdC). We investigated whether this resistance was due to the impairment of the Fas/Fas-ligand (FasL) system. MATERIALS AND METHODS: dFdC effects were studied in HuT78B1 and in the parental Fas-sensitive HuT78 cells exposed to inhibitors of the Fas/FasL system. RESULTS: FasL- and Fas-blocking antibodies did not interfere with dFdC-induced apoptosis in HuT78 cells, whereas inhibitors of caspase-8, -9, -1 or -3 had partial inhibitory effects. Notably, in HuT78B1 cells there was a markedly reduced dFdC accum…

Primary gastrointestinal involvement in non-Hodgkin's lymphomas.

This paper reviews primary gastrointestinal non-Hodgkin's lymphoma (GI-NHL). Every aspect of the topic is discussed though special attention is paid to histopathology and instrumental diagnosis as essential factors to stage the lymphoma and to determine an adequate therapy. Data from the most important works on the subject together with the results of our recent study of 40 primary GI-NHL are reported. Diverse findings by various authors are intentionally compared in a manner to present the work to the reader in the most critical way while trying to give an objective explanation of the different results on the basis of our own experience.

Antitumor profile of new phenothiazine derivatives

Cytotoxic and apoptotic effects of thiophenfurin in combination with retinoids in human promyelocitic leucemia HL60 cells

CCDC 611339: Experimental Crystal Structure Determination

Related Article: D.Simoni, M.Rossi, V.Bertolasi, M.Roberti, D.Pizzirani, R.Rondanin, R.Baruchello, F.P.Invidiata, M.Tolomeo, S.Grimaudo, S.Merighi, K.Varani, S.Gessi, P.A.Borea, S.Marino, S.Cavallini, C.Bianchi, A.Siniscalchi|2005|J.Med.Chem.|48|3337|doi:10.1021/jm0490235

CCDC 644638: Experimental Crystal Structure Determination

Related Article: D.Raffa, B.Maggio, S.Cascioferro, M.V.Raimondi, D.Schillaci, G.Gallo, G.Daidone, S.Plescia, F.Meneghetti, G.Bombieri, A.Di Cristina, R.M.Pipitone, S.Grimaudo, M.Tolomeo|2009|Eur.J.Med.Chem.|44|165|doi:10.1016/j.ejmech.2008.03.023