Author: Jorge Herrera

0000000001307154

AUTHOR

Jorge Herrera

Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

[EN] Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to beta-trifluoromethyl-alpha,beta-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active beta-trifluoromethyl delta-amino esters and optically active trifluoromethyl piperidones.

research product

CCDC 1535017: Experimental Crystal Structure Determination

Related Article: Miguel Espinosa, Jorge Herrera, Gonzalo Blay, Luz Cardona, M. Carmen Muñoz, José R. Pedro|2017|Org.Biomol.Chem.|15|3849|doi:10.1039/C7OB00595D

research product

CCDC 1535016: Experimental Crystal Structure Determination

Related Article: Miguel Espinosa, Jorge Herrera, Gonzalo Blay, Luz Cardona, M. Carmen Muñoz, José R. Pedro|2017|Org.Biomol.Chem.|15|3849|doi:10.1039/C7OB00595D

research product

PEPhysical Sciences and Engineering
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