6533b853fe1ef96bd12ad5a0
RESEARCH PRODUCT
Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines
M. Carmen MuñozMiguel EspinosaJorge HerreraGonzalo BlayLuz CardonaJosé R. Pedrosubject
Trifluoromethyl010405 organic chemistryChemistryOrganic ChemistryEnantioselective synthesischemistry.chemical_elementOptically active010402 general chemistry01 natural sciencesBiochemistryCopper0104 chemical sciencesStereocenterchemistry.chemical_compoundCatàlisiMethyl malonateFISICA APLICADAMichael reactionOrganic chemistryPhysical and Theoretical ChemistryQuímica orgànicaConjugatedescription
[EN] Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to beta-trifluoromethyl-alpha,beta-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active beta-trifluoromethyl delta-amino esters and optically active trifluoromethyl piperidones.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-14 | Organic & Biomolecular Chemistry |