0000000001308655

AUTHOR

Jose Lapetra

showing 4 related works from this author

Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach.

2014

© 2014 Fonseca et al. Background: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients. Copyright: Methods: We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selec…

GerontologyMaleAgingAntioxidantEpidemiologymedicine.medical_treatmenthumanosPhysiologymedicine.disease_causeAntioxidantschemistry.chemical_compoundanálisis de regresiónBlood plasmaMolecular Cell BiologyMedicine and Health Sciencesmediana edadCellular Stress Responsesglutatión peroxidasachemistry.chemical_classificationAged 80 and overancianoeducation.field_of_studyMultidisciplinaryGlutathione peroxidaseConfoundingQREpidemiology of AgingMiddle AgedPredimedestrés oxidativoCell ProcessesResearch DesignEpidemiological Methods and StatisticsRegression AnalysisMedicineFemaleAnatomyResearch ArticleClinical Research DesignEstrès oxidatiuSciencePopulationCardiologyResearch and Analysis MethodsMedicina preventivaEnvellimentantioxidantesmedicineHumansanálisis multifactorialMortalityeducationCardiovascular Disease EpidemiologyAgedPreventive medicineGlutathione PeroxidasePopulation BiologyCholesterolbusiness.industryBiology and Life SciencesGlutathioneCell BiologyCardiovascular riskBiomarker EpidemiologyOxidative StressCross-Sectional StudieschemistryOxidative stressMultivariate AnalysisCardiovascular AnatomyMorbiditybusinessOxidative stressestudios transversalesPLoS ONE
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A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk

2014

© 2014 Castro-Quezada et al. Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food freque…

GerontologyMalePhysiologyEpidemiologymodelos de riesgos proporcionaleshumanoslcsh:MedicineDieta mediterràniaFatsElderlyRisk Factorsíndice glucémicoCause of DeathMedicine and Health SciencesMedicinelcsh:Sciencemediana edadAged 80 and overeducation.field_of_studyancianoMultidisciplinaryDeath ratesGeographyGeographical regionsdietaMortality rateHazard ratioRegional geographyAge FactorsMiddle AgedGlycemic indexCardiovascular diseasesQuartilePhysiological ParametersCardiovascular DiseasesFemaleDietaResearch Articlemedicine.medical_specialtyPopulationCarbohydratesenfermedades cardiovascularesBlood sugarNational Death Indexcausas de muerteInternal medicineGlycemic loadDietary CarbohydratesMortalitatHumansfactores de riesgoObesityFatty acidsMortalityeducationCardiovascular Disease EpidemiologyGlycemicNutritionAgedProportional Hazards Modelsconducta alimentariabusiness.industryPhysical activitycarbohidratos dietéticosMalalties cardiovascularslcsh:RBody WeightBiology and Life SciencesPREDIMED studyNutrientsFeeding BehaviorGenitourinary cancersDietEarth sciencesGlucèmiaGeriatricsGlycemic IndexGlycemiclcsh:QMediterranean Basinbusinesshuman activities
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Effects of a Mediterranean Diet and physical activity on atherothrombosis biomarkers in high cardiovascular risk individuals

2019

Objective. Following a Mediterranean diet (MedDiet) and being physically active decrease cardiovascular risk. However, their individual and combined effects on atherothrombosis biomarkers are unexplored. Approach and Results. In 358 random volunteers from the PREDIMED trial (Prevencion con Dieta Mediterranea), we assessed the 1-year effects of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; N=120) or nuts (MedDiet-Nuts; N=119) versus a low-fat control diet (N=119), on atherothrombosis markers. In a secondary, observational approach, we studied the associations of 1-year changes in MedDiet adherence, physical activity (PA) levels, and their combination, with 1-year…

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MOESM1 of Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort s…

2019

Additional file 1. Additional figures and tables.

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