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RESEARCH PRODUCT
A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk
Itandehui Castro-quezadaAlmudena Sanchez VillegasRamon EstruchJordi Salas-salvadóDolores CorellaHelmut SchroederJacqueline Alvarez-perezMaria Dolores Ruiz-lopezReyes ArtachoEmilio RosMònica BullóMaria-isabel CovasValentina Ruiz-gutierrezMiguel Ruiz-canelaPilar Buil-cosialesEnrique Gomez-graciaJose LapetraXavier PintoFernando ArosMiquel Fiol SalaRosa Maria Lamuela-raventosMiguel Angel Martinez-gonzalezLuis Serra-majemPredimed Study Investigatorssubject
GerontologyMalePhysiologyEpidemiologymodelos de riesgos proporcionaleshumanoslcsh:MedicineDieta mediterràniaFatsElderlyRisk Factorsíndice glucémicoCause of DeathMedicine and Health SciencesMedicinelcsh:Sciencemediana edadAged 80 and overeducation.field_of_studyancianoMultidisciplinaryDeath ratesGeographyGeographical regionsdietaMortality rateHazard ratioRegional geographyAge FactorsMiddle AgedGlycemic indexCardiovascular diseasesQuartilePhysiological ParametersCardiovascular DiseasesFemaleDietaResearch Articlemedicine.medical_specialtyPopulationCarbohydratesenfermedades cardiovascularesBlood sugarNational Death Indexcausas de muerteInternal medicineGlycemic loadDietary CarbohydratesMortalitatHumansfactores de riesgoObesityFatty acidsMortalityeducationCardiovascular Disease EpidemiologyGlycemicNutritionAgedProportional Hazards Modelsconducta alimentariabusiness.industryPhysical activitycarbohidratos dietéticosMalalties cardiovascularslcsh:RBody WeightBiology and Life SciencesPREDIMED studyNutrientsFeeding BehaviorGenitourinary cancersDietEarth sciencesGlucèmiaGeriatricsGlycemic IndexGlycemiclcsh:QMediterranean Basinbusinesshuman activitiesdescription
© 2014 Castro-Quezada et al. Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR =2.15 (95% CI: 1.15-4.04); P for trend =0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-cause mortality only when subjects were younger than 75 years. Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-24 |