0000000001309659
AUTHOR
Vanessa Lewe
Reversible Covalent and Supramolecular Functionalization of Water-Soluble Gold(I) Complexes.
The ligation of gold(I) metalloamphiphiles with biomolecules is reported, using water-soluble AuI -N-alkynyl substituted maleimide complexes. For this purpose, two different polar ligands were applied: 1) a neutral, dendritic tetraethylene glycol-functionalized phosphane and 2) a charged, sulfonated N-heterocyclic carbene (NHC). The retro Diels-Alder reaction of a furan-protected maleimide gold(I) complex, followed by cycloaddition with a diene-functionalized biotin under mild conditions leads to a novel gold(I) metalloamphiphile. The strong streptavidin-biotin binding affinity in buffered aqueous solution of the resulting biotin alkynyl gold(I) phosphane conjugate remains intact. The cytot…
A clickable NHC–Au(i)-complex for the preparation of stimulus-responsive metallopeptide amphiphiles
We report the synthesis of an alkyne functionalised NHC-Au(i)-complex which is conjugated with amphiphilic oligopeptides using a copper(i) catalysed cycloaddition. The resulting Au(i)-metalloamphiphiles are shown to self-assemble into charge-regulated stimulus-responsive supramolecular polymers in water via a weakly cooperative polymerisation mechanism.
Impact of sample history and solvent effects on pathway control in the supramolecular polymerisation of Au(i)-metallopeptide amphiphiles
We investigate the kinetics of the supramolecular polymerisation of an Au(i)-metallopeptide amphiphile that assembles into exceptionally long and rigid nanofibers.
CCDC 1532063: Experimental Crystal Structure Determination
Related Article: Benedict Kemper, Maximilian von Gröning, Vanessa Lewe, Daniel Spitzer, Tobias Otremba, Natascha Stergiou, Dieter Schollmeyer, Edgar Schmitt, Bart Jan Ravoo, Pol Besenius|2017|Chem.-Eur.J.|23|6048|doi:10.1002/chem.201700588