0000000001309929

AUTHOR

Błażej Gierczyk

The influence of fluorine position on the properties of fluorobenzoxaboroles

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.

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Novel 2,6-disubstituted phenylboronic compounds - Synthesis, crystal structures, solution behaviour and reactivity

Abstract 2,6-Diformylphenylboronic acid has been synthesized and characterized both in the solid state as well as in solution. In crystal, an unusual structural pattern has been found with the formation of intermolecular hydrogen bonds by B(OH) 2 and CHO groups as well as water molecules. In solution tautomeric equilibrium with the formation of oxaborole ring by one of the formyl groups was proved on the basis of multinuclear NMR spectroscopy. The title compound reacts with secondary mono- and diamines to form various types of substituted benzoxaboroles, which have been characterized by XRD and spectroscopic methods.

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CCDC 1029677: Experimental Crystal Structure Determination

Related Article: Agnieszka Adamczyk-Woźniak, Krzysztof Ejsmont, Błażej Gierczyk, Ewa Kaczorowska, Alicja Matuszewska, Grzegorz Schroeder, Andrzej Sporzyński, Bartosz Zarychta|2015|J.Organomet.Chem.|788|36|doi:10.1016/j.jorganchem.2015.04.026

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CCDC 1029678: Experimental Crystal Structure Determination

Related Article: Agnieszka Adamczyk-Woźniak, Krzysztof Ejsmont, Błażej Gierczyk, Ewa Kaczorowska, Alicja Matuszewska, Grzegorz Schroeder, Andrzej Sporzyński, Bartosz Zarychta|2015|J.Organomet.Chem.|788|36|doi:10.1016/j.jorganchem.2015.04.026

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CCDC 1027467: Experimental Crystal Structure Determination

Related Article: Agnieszka Adamczyk-Woźniak, Małgorzata K. Cabaj, Paulina M. Dominiak, Patrycja Gajowiec, Błażej Gierczyk, Jacek Lipok, Łukasz Popenda, Grzegorz Schroeder, Ewelina Tomecka, Piotr Urbański, Dorota Wieczorek, Andrzej Sporzyński|2015|Bioorg.Chem.|60|130|doi:10.1016/j.bioorg.2015.05.004

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