The influence of fluorine position on the properties of fluorobenzoxaboroles

6533b7dcfe1ef96bd1272c97

RESEARCH PRODUCT

The influence of fluorine position on the properties of fluorobenzoxaboroles

ŁUkasz Popenda Paulina M. Dominiak Andrzej Sporzyński Małgorzata Katarzyna Cabaj Grzegorz Schroeder Ewelina Tomecka Dorota Wieczorek Błażej Gierczyk Patrycja Gajowiec Agnieszka Adamczyk-woźniak Jacek Lipok Piotr M. Urbański

subject

Boron Compounds Models Molecular crystal structure Antifungal Agents Magnetic Resonance Spectroscopy Halogenation Stereochemistry Antifungal drug chemistry.chemical_element Crystal structure Crystallography X-Ray Biochemistry benzoxaboroles Isomerism Drug Discovery Humans Molecular Biology tavaborole Tavaborole Chemistry Organic Chemistry antifungal activity Fungi Fluorine Bridged Bicyclo Compounds Heterocyclic Mycoses Fluorine

description

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.

year	journal	country	edition	language
2015-03-04	Bioorganic Chemistry

10.1016/j.bioorg.2015.05.004 http://www.sciencedirect.com/science/article/pii/S0045206815000425

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