0000000001309990

AUTHOR

Víctor Ivo Fouz

showing 2 related works from this author

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines.

2018

Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GS…

Aparato digestivo-EnfermedadesThiosemicarbazonesSpectrometry Mass Electrospray IonizationColorectal cancerColon carcinoma010402 general chemistryCrystallography X-RayThiosemicarbazone01 natural sciencesBiochemistryInorganic Chemistrychemistry.chemical_compoundColon carcinomaCell Line TumorSpectroscopy Fourier Transform InfraredmedicineHumansMolecular magnetismDigestive organs-DiseasesMolecular Structure010405 organic chemistryChemistryMyoglobinCytochromes cGlutathioneChemistry Inorganicmedicine.diseaseMolecular biologyGlutathioneQuímica inorgánica0104 chemical sciencesCell cultureDrug Screening Assays AntitumorColorectal NeoplasmsCopperJournal of inorganic biochemistry
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CCDC 1424631: Experimental Crystal Structure Determination

2017

Related Article: Javier García-Tojal, Rubén Gil-García, Víctor Ivo Fouz, Gotzon Madariaga, Luis Lezama, María S. Galletero, Joaquín Borrás, Friederike I. Nollmann, Carlos García-Girón, Raquel Alcaraz, Mónica Cavia-Saiz, Pilar Muñiz, Òscar Palacios, Katia G. Samper, Teófilo Rojo|2018|J.Inorg.Biochem.|180|69|doi:10.1016/j.jinorgbio.2017.12.005

Space GroupCrystallographyCrystal Systemcatena-(bis(mu-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioiato)-bis(nitrato)-di-copper)Crystal StructureCell ParametersExperimental 3D Coordinates
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