0000000001309998

AUTHOR

ÒScar Palacios

showing 3 related works from this author

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines.

2018

Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GS…

Aparato digestivo-EnfermedadesThiosemicarbazonesSpectrometry Mass Electrospray IonizationColorectal cancerColon carcinoma010402 general chemistryCrystallography X-RayThiosemicarbazone01 natural sciencesBiochemistryInorganic Chemistrychemistry.chemical_compoundColon carcinomaCell Line TumorSpectroscopy Fourier Transform InfraredmedicineHumansMolecular magnetismDigestive organs-DiseasesMolecular Structure010405 organic chemistryChemistryMyoglobinCytochromes cGlutathioneChemistry Inorganicmedicine.diseaseMolecular biologyGlutathioneQuímica inorgánica0104 chemical sciencesCell cultureDrug Screening Assays AntitumorColorectal NeoplasmsCopperJournal of inorganic biochemistry
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The metal binding abilities of Megathura crenulata metallothionein (McMT) in the frame of gastropoda MTs.

2011

Metallothioneins (MTs) are proteins that play a major role in metal homeostasis and/or detoxification in all kind of organisms. The MT gene/protein system of gastropod molluscs provides an invaluable model to study the diversification mechanisms that have enabled MTs to achieve metal-binding specificity through evolution. Most pulmonate gastropods, particularly terrestrial snails, harbor three paralogous isogenes encoding three MT isoforms with different metal binding preferences: the highly specific CdMT and CuMT isoforms, for cadmium and copper respectively, and the unspecific Cd/CuMT isoform. Megathura crenulata is a non-pulmonate gastropod in which only one MT isogene has so far been re…

Gene isoformSpectrometry Mass Electrospray Ionizationanimal structuresGastropodaPeptidePlasma protein bindingMegathura crenulataBiochemistryInorganic ChemistryProtein sequencingGastropodaMetallothioneinAnimalsGenechemistry.chemical_classificationbiologyChemistryEcologybiology.organism_classificationZincBiochemistryMetalsMetallothioneinCopperCadmiumProtein BindingJournal of inorganic biochemistry
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CCDC 1424631: Experimental Crystal Structure Determination

2017

Related Article: Javier García-Tojal, Rubén Gil-García, Víctor Ivo Fouz, Gotzon Madariaga, Luis Lezama, María S. Galletero, Joaquín Borrás, Friederike I. Nollmann, Carlos García-Girón, Raquel Alcaraz, Mónica Cavia-Saiz, Pilar Muñiz, Òscar Palacios, Katia G. Samper, Teófilo Rojo|2018|J.Inorg.Biochem.|180|69|doi:10.1016/j.jinorgbio.2017.12.005

Space GroupCrystallographyCrystal Systemcatena-(bis(mu-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioiato)-bis(nitrato)-di-copper)Crystal StructureCell ParametersExperimental 3D Coordinates
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