0000000001310354
AUTHOR
Cheng Fan
Mechanistic Studies on the Metal-Free Activation of Dihydrogen by Antiaromatic Pentarylboroles
The perfluoro- and perprotiopentaphenylboroles 1 and 2 react with dihydrogen to effect H–H bond cleavage and formation of boracyclopentene products. The mechanism of this reaction has been studied experimentally through evaluation of the kinetic properties of the slower reaction between 2 and H2. The reaction is first-order in both [borole] and [H2] with activation parameters of ΔH⧧ = 34(8) kJ/mol and ΔS⧧ = −146(25) J mol–1 K–1. A minimal kinetic isotope effect of 1.10(5) was observed, suggesting an asynchronous geometry for H–H cleavage in the rate-limiting transition state. To explain the stereochemistry of the observed products, a ring-opening/ring-closing mechanism is proposed and suppo…
Mechanistic Studies on the Metal-Free Activation of Dihydrogen by Antiaromatic Pentarylboroles
The perfluoro- and perprotiopentaphenylboroles 1 and 2 react with dihydrogen to effect H-H bond cleavage and formation of boracyclopentene products. The mechanism of this reaction has been studied experimentally through evaluation of the kinetic properties of the slower reaction between 2 and H(2). The reaction is first-order in both [borole] and [H(2)] with activation parameters of ΔH(‡) = 34(8) kJ/mol and ΔS(‡) = -146(25) J mol(-1) K(-1). A minimal kinetic isotope effect of 1.10(5) was observed, suggesting an asynchronous geometry for H-H cleavage in the rate-limiting transition state. To explain the stereochemistry of the observed products, a ring-opening/ring-closing mechanism is propos…
Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Abstract Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other breast cancer subtypes, 28 MBCs were compared with common breast cancers using comparative genomic hybridization, transcriptional profiling, and reverse-phase protein arrays and by sequencing for common breast cancer mutations. MBCs showed unique DNA copy number aberrations compared with common breast cancers. PIK3CA mutations were detected in 9 of 19 MBCs (47.4%) versus 80 of 232 hormone receptor–positive cancers (34.5%; P = 0.32), 17 of 75 HER-2–positive samples (22.7%; P = 0.04), 20 of 240 basal-like c…
Dihydrogen Activation by Antiaromatic Pentaarylboroles
Facile metal-free splitting of molecular hydrogen (H2) is crucial for the utilization of H2 without the need for toxic transition-metal-based catalysts. Frustrated Lewis pairs (FLPs) are a new class of hydrogen activators wherein interactions with both a Lewis acid and a Lewis base heterolytically disrupt the hydrogen−hydrogen bond. Here we describe the activation of hydrogen exclusively by a boron-based Lewis acid, perfluoropentaphenylborole. This antiaromatic compound reacts extremely rapidly with H2 in both solution and the solid state to yield boracyclopent-3-ene products resulting from addition of hydrogen atoms to the carbons α to boron in the starting borole. The disruption of antiar…
Dihydrogen Activation by Antiaromatic Pentaarylboroles
Facile metal-free splitting of molecular hydrogen (H(2)) is crucial for the utilization of H(2) without the need for toxic transition-metal-based catalysts. Frustrated Lewis pairs (FLPs) are a new class of hydrogen activators wherein interactions with both a Lewis acid and a Lewis base heterolytically disrupt the hydrogen-hydrogen bond. Here we describe the activation of hydrogen exclusively by a boron-based Lewis acid, perfluoropentaphenylborole. This antiaromatic compound reacts extremely rapidly with H(2) in both solution and the solid state to yield boracyclopent-3-ene products resulting from addition of hydrogen atoms to the carbons alpha to boron in the starting borole. The disruption…
CCDC 777076: Experimental Crystal Structure Determination
Related Article: Cheng Fan, L.G.Mercier, W.E.Piers, H.M.Tuononen, M.Parvez|2010|J.Am.Chem.Soc.|132|9604|doi:10.1021/ja105075h
CCDC 777075: Experimental Crystal Structure Determination
Related Article: Cheng Fan, L.G.Mercier, W.E.Piers, H.M.Tuononen, M.Parvez|2010|J.Am.Chem.Soc.|132|9604|doi:10.1021/ja105075h
CCDC 912008: Experimental Crystal Structure Determination
Related Article: Adrian Y. Houghton , Virve A. Karttunen , Cheng Fan , Warren E. Piers , and Heikki M. Tuononen|2013|J.Am.Chem.Soc.|135|941|doi:10.1021/ja311842r