0000000001310794

AUTHOR

Clarence A. Mgina

showing 7 related works from this author

Flavonoids from Erythrina schliebenii

2017

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).

Antitubercular AgentsPharmaceutical ScienceMicrobial Sensitivity TestsPlant RootsTanzania01 natural sciencesErythrina schliebeniiAnalytical ChemistryMycobacterium tuberculosischemistry.chemical_compoundDrug DiscoveryBotanyHumansta116Nuclear Magnetic Resonance BiomolecularErythrinaEC50FlavonoidsPharmacologyStem barkMolecular StructureTraditional medicinebiology010405 organic chemistryOrganic ChemistryErythrina schliebeniiPterocarpanMycobacterium tuberculosisIsoflavonesbiology.organism_classification0104 chemical sciences3. Good health010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryToxicityPlant BarkMolecular MedicineDrug Screening Assays AntitumorCancer cell linesJournal of Natural Products
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CCDC 1498874: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

3-(34-dimethoxy-5-(3-methylbut-2-en-1-yl)phenyl)-57-dihydroxy-4H-chromen-4-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1498877: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates567-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
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CCDC 1498873: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

Space GroupCrystallography57-dihydroxy-2-(4-methoxy-35-bis(3-methylbut-2-en-1-yl)phenyl)-23-dihydro-4H-chromen-4-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1498875: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

Space GroupCrystallography57-dihydroxy-3-(4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-4H-chromen-4-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1498876: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters567-trimethoxy-2-(4-methoxyphenyl)-23-dihydro-4H-chromen-4-oneExperimental 3D Coordinates
researchProduct

CCDC 1498878: Experimental Crystal Structure Determination

2017

Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-(6-hydroxy-234-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-oneExperimental 3D Coordinates
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