0000000001310794
AUTHOR
Clarence A. Mgina
Flavonoids from Erythrina schliebenii
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).
CCDC 1498874: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839
CCDC 1498877: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839
CCDC 1498873: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839
CCDC 1498875: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839
CCDC 1498876: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839
CCDC 1498878: Experimental Crystal Structure Determination
Related Article: Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, Máté Erdélyi|2017|J.Nat.Prod.|80|377|doi:10.1021/acs.jnatprod.6b00839