6533b855fe1ef96bd12afe9b
RESEARCH PRODUCT
Flavonoids from Erythrina schliebenii
Fangfang PanMáté ErdélyiJoan J. E. MunissiJoan J. E. MunissiMsim KomboKari RissanenAmra GruhonjicBin WangYu LuPaul A. FitzpatrickClarence A. MginaStephen S. NyandoroStephen S. Nyandorosubject
Antitubercular AgentsPharmaceutical ScienceMicrobial Sensitivity TestsPlant RootsTanzania01 natural sciencesErythrina schliebeniiAnalytical ChemistryMycobacterium tuberculosischemistry.chemical_compoundDrug DiscoveryBotanyHumansta116Nuclear Magnetic Resonance BiomolecularErythrinaEC50FlavonoidsPharmacologyStem barkMolecular StructureTraditional medicinebiology010405 organic chemistryOrganic ChemistryErythrina schliebeniiPterocarpanMycobacterium tuberculosisIsoflavonesbiology.organism_classification0104 chemical sciences3. Good health010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryToxicityPlant BarkMolecular MedicineDrug Screening Assays AntitumorCancer cell linesdescription
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-23 | Journal of Natural Products |