Experimental Evidence for an Attractive p-φ Interaction

Physical review letters 127(17), 172301 (2021). doi:10.1103/PhysRevLett.127.172301

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flo…

Synthesis, spectroscopic characterization and antiproliferative activity of two platinum(II) complexes containing N-donor heterocycles

Abstract Novel mononuclear complexes of Pt(II), cis -[PtCl 2 (DMSO)HL]·2DMSO ( 1 ), where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5- a ]pyrimidine-6-carboxylic acid and Pt(bdt)Cl 2 ( 2 ), where bdt = [2,4-bis(5,6-diphenyl-1,2,4-triazin-3yl)-pyridine] have been synthesized and characterized by elemental analysis, IR and 1 H NMR spectroscopy and X-ray crystallography diffraction analyses. The molecular structure of ( 1 ) shows that Pt(II) ion has a square planar geometry with N(3) bonded heterocycle ligand, two cis chloride anions and S-bonded dimethylsulfoxide. The antiproliferative activity of complexes ( 1 ) and ( 2 ) has been tested in vitro against HepG2 human hepatoma cells and non…

J/ψ suppression at forward rapidity in Pb–Pb collisions at sNN=5.02 TeV

The inclusive J/$\psi$ production has been studied in Pn-Pb and pp collisions at the centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}=5.02$ TeV, using the ALICE detector at the CERN LHC. The J/$\psi$ meson is reconstructed, in the centre-of-mass rapidity interval $2.5<y<4$ and in the transverse-momentum range $p_{\rm T}<12$ GeV/$c$, via its decay to a muon pair. In this Letter, we present results on the inclusive J/$\psi$ cross section in pp collisions at $\sqrt{s}=5.02$ TeV and on the nuclear modification factor $R_{\rm AA}$. The latter is presented as a function of the centrality of the collision and, for central collisions, as a function of the transverse momentum $p_{\rm T}$ of…

Production of Muons from Heavy Flavor Decays at Forward Rapidity inppand Pb-Pb Collisions atsNN=2.76  TeV

The ALICE Collaboration has measured the inclusive production of muons from heavy-flavor decays at forward rapidity, 2.5 < y < 4, in pp and Pb-Pb collisions at root s(NN) = 2.76 TeV. The p(t)-differential inclusive cross section of muons from heavy-flavor decays in pp collisions is compared to perturbative QCD calculations. The nuclear modification factor is studied as a function of p(t) and collision centrality. A weak suppression is measured in peripheral collisions. In the most central collisions, a suppression of a factor of about 3-4 is observed in 6 < p(t) < 10 GeV/c. The suppression shows no significant p(t) dependence.

(S)-2-[(2-Hydroxybenzyl)azaniumyl]-4-(methylsulfanyl)butanoate

The zwitterionic title compound, C12H17NO3S, is a reduced Schiff base derived from (S)-N-(2-hydroxybenzylidene)methionine. An intramolecular interaction between the N&amp;#8212;H and carboxylate groups forms a roughly planar (r.m.s. deviation = 0.1405&amp;#8197;&amp;#197;) five-membered ring containing the H(N), N, C&amp;#945;, C(carboxylate) and O atoms in a pentagonal conformation. In the crystal, a supramolecular triangle-shaped motif is generated by molecules held together by O&amp;#8212;H...O and N&amp;#8212;H...O hydrogen bonds.

Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4’-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists

Abstract Recently we identified ( R , S )-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ( 6 ) as a potent non-competitive AMPA receptor antagonist able to prevent epileptic seizures. We report here the optimized synthesis of compound 6 , its resolution by chiral preparative HPLC, and the absolute configuration of ( R )-enantiomer established by X-ray diffractometry. The biological tests of the single enantiomers revealed that higher anticonvulsant and antagonistic effects reside in ( R )-enantiomer as also suggested by molecular modeling studies.

Behavioral and psychological effects of coronavirus disease-19 quarantine in patients with dementia

Background: In March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers. Methods: This is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD),…

Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II).

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1 H and 1 3 C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu I I (2-BZP) 2 ] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu I I (2-BZP) 2 ] and [Pt I I (2-BZP) 2 ] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 μM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10…

Synthesis, solution behaviour and potential anticancer activity of new trinuclear organometallic palladium(II) complex of S-1-phenylethyl dithiooxamide: Comparison with the trinuclear heterobimetallic platinum(II) analogue

Abstract Addition of H2R2DTO (R = {S}-1-phenylethyl and DTO = dithiooxamide) to the bis(benzonitrile)palladium(II) chloride complex in chloroform afforded the mononuclear Pd(DTO)2·2HCl complex. The complex treated with NaHCO3 for removing of HCl and then reacted with [Pd(ƞ3-allyl)(µ-Cl)]2 for preparation of a new trimetallic organopalladium(II) complex. The molecular structure of the trimetallic complex was determined by X-ray diffraction indicating a planar geometry around each palladium center. Also, variable temperature spectroscopy for this complex was performed in CDCl3 in the range 298–390 K, and simulations of the dynamic spectra were performed using the gNMR program. A comparison be…

Crystal and molecular structure of the tris(1,10-phenanthroline)potassium salt of μ-hydridobis[pentacarbonylchromium(0)]

Abstract The crystal and molecular structure of [K(phen)3][Cr2(CO)10(μ-H)] has been determined by X-ray diffraction. The compound crystallizes in the space group P 1 with a 11.884(4), b 13.968(4), c 15.612(6) A, α 112.6(1), β 99.7(1) and γ 106.2(1)° and Z = 2. The structure was refined to R = 0.066 and RW = 0.067 for 3692 counter data with I ⩾ 3σ(I). The complex anion [Cr2(CO)10(μ-H)] adopts a bent Cr-H-Cr configuration with the equatorial carbonyl groups of the two independent Cr(CO)5 moieties in an eclipsed configuration. The Cr⋯Cr distance is 3.394(3) A and the two CrH bonds are 1.74(7) and 1.71(7) A. The CrHCr bond angle is 159(3)°. In the dimeric complex cation [K(phen)3]2, located …

(Dipyrido[3,2-a:2',3'-c]phenazine)(glycinato)copper(II) perchlorate: a novel DNA-intercalator with anti-proliferative activity against thyroid cancer cell lines.

Abstract A novel copper(II) heteroleptic complex of dipyrido[3,2-a:2′,3′-c]phenazine (dppz) and glycinato (gly) as chelating ancillary ligand, [Cu(dppz)(gly)]ClO 4 ( 1 ), was synthesized and characterized. X-ray crystallography revealed that the coordination geometry of the cationic [Cu(dppz)(gly)] + unit is hexacoordinated and shows a distorted octahedral coordination geometry in the solid state, with the N,N and N,O chelating atoms of dppz and glycinato, respectively, in the square plane and in which the planar units are connected in a monodimensional polymeric array by the apical copper coordination of the second carboxylic oxygen atom. Biological assays showed that 1 exhibits a remarkab…

Jet-like correlations with neutral pion triggers in pp and central Pb–Pb collisions at 2.76 TeV

Physics letters / B B763, 238 - 250 (2016). doi:10.1016/j.physletb.2016.10.048

Λc+ Production and Baryon-to-Meson Ratios in pp and p -Pb Collisions at sNN=5.02  TeV at the LHC

The prompt production of the charm baryon Λ c + and the Λ c + / D 0 production ratios were measured at midrapidity with the ALICE detector in p p and p -Pb collisions at s NN = 5.02 TeV . These new measurements show a clear decrease of the Λ c + / D 0 ratio with increasing transverse momentum ( p T ) in both collision systems in the range 2 p T 12 GeV / c , exhibiting similarities with the light-flavor baryon-to-meson ratios p / π and Λ / K S 0 . At low p T , predictions that include additional color-reconnection mechanisms beyond the leading-color approximation, assume the existence of additional higher-mass charm-baryon states, or include hadronization via coalescence can describe the dat…

On the G‐quadruplex binding of a new class of Ni(II), Cu(II) and Zn(II) salphen‐like complexes

The involvement of non-canonical DNA structures, such as Gquadruplex (G4) DNA, in cancer development and progression has set the pace towards the renaissance of DNA-binding metal complexes. In this work, we report the DNA-binding of three Ni(II), Cu(II), Zn(II) complexes of a salphen-like N4-donor ligand, bearing two imidazole groups condensed with a phenylenediamine moiety. Both duplex and G4 DNAs derived from human telomeres (hTelo), and a sequence mimicking the promoter of the oncogene myc (c-myc) were studied. UV-Vis and circular dichroism spectroscopic binding studies pointed out that, while all the three complexes bind the selected oligonucleotides, the Cu(II) derivative is the strong…

The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

IntroductionPrevious studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine.MethodsThe study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after …

On the G‐Quadruplex Binding of a New Class of Nickel(II), Copper(II), and Zinc(II) Salphen‐Like Complexes

Ruthenium(II) and platinum(II) homo- and heterobimetallic complexes: Synthesis, crystal structures, theoretical calculations and biological studies

Four Ru-Pd heterobimetallic complexes, each one in two different coordination modes (NNSS and NS) having metals connected by a binucleating dialkyldithiooxamidate [N(R)SC-CS(R)N] [R = methyl, ethyl, n-butyl and isopropyl], were prepared by reacting the monochelate [(trinpropyl-phosphine)ClPd(HR2C2N2S2κ-S,S-Pd)] with [(η6-p-cymene)RuCl2]2. Furthermore, two palladium homobimetallic complexes having two (trinpropyl-phosphine)ClPd moieties joined by a diethyldithiooxamidate in both κ-N,S Pd, κ-N',S' Pd' and κ-N,N' Pd, κ-S,S' Pd' coordination modes were synthesized. For both kinds of complexes, homo- and heterobimetallic, at room temperature and in chloroform solution, the NNSS coordination mode…

Particle identification in ALICE: a Bayesian approach

We present a Bayesian approach to particle identification (PID) within the ALICE experiment. The aim is to more effectively combine the particle identification capabilities of its various detectors. After a brief explanation of the adopted methodology and formalism, the performance of the Bayesian PID approach for charged pions, kaons and protons in the central barrel of ALICE is studied. PID is performed via measurements of specific energy loss ($\mathrm{d}E/\mathrm{d}x$) and time-of-flight. PID efficiencies and misidentification probabilities are extracted and compared with Monte Carlo simulations using high-purity samples of identified particles in the decay channels ${\rm K}^0_S \righta…

Triorganotin(IV) derivatives of 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid. Synthesis, spectroscopic characterization, in vitro antimicrobial activity and X-ray crystallography

Triorganotin(IV) complexes of the 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid (HL), Me 3 SnL(H 2 O), ( 1 ), [ n -Bu 3 SnL] 2 (H 2 O), ( 2 ), Ph 3 SnL(MeOH), ( 3 ), were synthesized by reacting the amino acid with organotin(IV) hydroxides or oxides in refluxing methanol. The complexes have been characterized by elemental analysis, 1 H, 13 C and 119 Sn NMR, IR, Raman and 119 Sn Mossbauer spectroscopic techniques. Single crystal X-ray diffraction data were obtained for compounds ( 2 ) and ( 3 ). Ph 3 SnL(MeOH) presents a trigonal bipyramidal structure with the organic groups on the equatorial plane and the axial positions occupied by a ligand molecule, coordinated …

Synthesis, infrared and M�ssbauer characterization and X-ray crystal structure of 1,10-phenanthrolinium tetrachloromethoxy phenylantimonate(V)

The compound has been characterized by X-ray crystal structure determination, Mossbauer and i.r. spectroscopy. It crystallizes in the monoclinic space groupP21/c (No. 14) witha=24.228(4),b=8.335(2),c=23.975(4) A,β=117.83(3)° andZ=8. Least-squares refinement on 3749 observed reflections gave finalR=0.034 (Rw=0.037). The compound is constituted by [(C6H5)SbCl4OMe]− anions andphenH+cations. The coordination polyhedron about Sb is an octahedron (Sb-Cl 2.416(3), Sb-O 1.962(7) and Sb-C 2.138(9) A). The whole structure is characterized by two short contacts (O(1)⋯N(2) 2.76(1) O(2)⋯N(4) 2.75(1) A) involving the methoxy oxygens of the two independent anionic units [(C6H5)SbCl4OMe]− and two nitrogens…

Effects of electron donating/withdrawing groups in the 5-substituted-2-hydroxybenzaldehyde on the synthesis of neutral cubanes with a NiII4O4core: synthesis, crystal structures and magnetic properties

Two tetranuclear cubane-like nickel(II) complexes of formula [Ni4(CH3O)4(L1)4(CH3OH)4] (1) and [Ni4(CH3O)4(L2)4(CH3OH)4] (2) (HL1 = 2-hydroxybenzaldehyde and HL2 = 2-hydroxy-5-methylbenzaldehyde) have been prepared by the reaction of NiCl2·6H2O with methanolic solutions of HL1 and HL2 in the presence of triethylamine at room temperature. Complexes 1 and 2 have been characterized by elemental analyses, IR spectra and single-crystal X-ray diffraction. The X-ray crystal structure analysis revealed that 1 and 2 have a cubane-type structural topology with four Ni(II) ions and four methoxo-oxygen atoms regularly alternating at the corners. Each metal ion in 1 and 2 is six-coordinate in a distorte…

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