0000000001311762
AUTHOR
José Bonet Navarro
La realización sustitutiva de la subasta judicial en el Anteproyecto de Código Procesal Civil chileno. Reflexiones a partir de su regulación en la Ley de Enjuiciamiento Civil española
Speaking of the presentation of the civil procedural draft bill, the author intends to contribute to cover some of the imperfections and omissions related to the regulation ofattachment goods or rights, that come to substitute other traditional means of execution such as the judicative auction or even the so called judicative antichresis; in the light of doctrine, experience and the Spanish Law.
Especialidades en el proceso administrativo español sobre personal
This is a study of the eminent domains foreseen in the Spanish administrative procedure concerning personnel. The main procedural issues raised by the proceedings such as its adequacy, quantification, jurisdiction and competence are analyzed, starting from an approximation to the concept of personnel matters and from the juridical nature of this proceeding as being common to eminent domains. Particularly, the procedural specialties are studied either being proceeding independently from the adequate procedural action or those foreseen for given assumptions.
Regulation of tumour cell sensitivity to TNF-induced oxidative stress and cytotoxicity: Role of glutathione
Glutathione (GSH) and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor (TNF). Buthionine sulphoximine (BSO), a selective inhibitor of GSH synthesis, inhibits tumour growth and increases recombinant human TNF (rhTNF)-alpha cytoxicity in vitro. Administration of sublethal doses of rhTNF-alpha to Ehrlich ascites-tumour (EAT)-bearing mice induces oxidative stress (as measured by increases in intracellular peroxide levels, O2.- generation and mitochondrial GSSG). ATP-induced selective GSH depletion, when combined with rhTNF-alpha administration, affords a 61% inhibition of tumour growth and results in a significant extent of host survival. Administra…
El procedimiento monitorio en el anteproyecto de código procesal chileno : Algunas consideraciones a partir de la experiencia en derecho español
Se estudian las características del proceso monitorio en el anteproyecto de código procesal civil chileno. En este análisis se realiza primero un estudio sistemático del ACPC, y enseguida se analiza críticamente el anteproyecto dejándose en evidencia sus vacíos e imperfecciones. Con ello, y sobre todo al especificarlas, contribuye precisa y claramente a mejorarlo. The author deals witch the characteristics of the admonitory proceedings in the Chilean civil procedural code draft bill. He first does a systematic study of this draft bill, and then critically analyzes in finding loopholes and imperfections. By doing this, and because he specifies them, he contributes clearly and precisely to im…
Blood Glutathione as an Index of Radiation-Induced Oxidative Stress in Mice and Humans
Abstract The effect of x-rays on GSH and GSSG levels in blood was studied in mice and humans. An HPLC method that we recently developed was applied to accurately determine GSSG levels in blood. The glutathione redox status (GSH/GSSG) decreases after irradiation. This effect is mainly due to an increase in GSSG levels. Mice received single fraction radiotherapy, at total doses of 1.0 to 7.0 Gy. Changes in GSSG in mouse blood can be detected 10 min after irradiation and last for 6 h within a range of 2.0–7.0 Gy. The highest levels of GSSG (20.1 ± 2.9 μ M), a 4.7-fold increase as compared with controls) in mouse blood are found 2 h after radiation exposure (5 Gy). Breast and lung cancer patien…
Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo
The relationship among cancer growth, the glutathione redox cycle and the antioxidant system was studied in blood and in tumour cells. During cancer growth, the glutathione redox status (GSH/GSSG) decreases in blood of Ehrlich ascites tumour-bearing mice. This effect is mainly due to an increase in GSSG levels. Two reasons may explain the increase in blood GSSG: (a) the increase in peroxide production by the tumour that, in addition to changes affecting the glutathione-related and the antioxidant enzyme activities, can lead to GSH oxidation within the red blood cells; and (b) an increase of GSSG release from different tissues into the blood. GSH and peroxide levels are higher in the tumour …
Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo.
Low rates of cellular proliferation are associated with low GSH content and enhanced sensitivity of Ehrlich ascites-tumour (EAT) cells to the cytotoxic effects of recombinant human tumour necrosis factor (rhTNF-alpha). Buthionine sulphoximine, a selective inhibitor of GSH synthesis, inhibited tumour growth and increased rhTNF-alpha cytoxicity in vitro. Administration of sublethal doses (10(6)units/kg per day) of rhTNF-alpha to EAT-bearing mice promoted oxidative stress (as measured by increases in intracellular peroxide levels, O2(-); generation and mitochondrial GSSG) and resulted in a slight reduction (19%) in tumour cell number when controls showed the highest rate of cellular proliferat…
Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays
ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (GSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chemotherapy and radiation, but the usefulness of this depletion depends on whether the levels of GSH can be reduced in the tumour relative to normal tissues. We report here that administration of ATP in combination with diethylmaleate and X-rays leads to complete regression of 95% of Ehrlich ascites tumours in mice. This shows that an aggressive tumour can be eliminated by using a therapy based on modulation of GSH levels in cancer cells.
Tutoriales para la docencia del Derecho Procesal Penal. Un ejemplo de utilización de Wink con mapas conceptuales y Power Point
Presentació d'experiències d'innovació docent (Panell II).Duración: 15 M