0000000001311806
AUTHOR
Aleix González Del Campo
showing 4 related works from this author
Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolone…
2022
A diastereo- and enantioselective organocatalytic aldol reaction between alkylidenepyrazolones and trifluoromethyl ketones leading to chiral tertiary alcohols bearing a trifluoromethyl group is presented. The methodology is based on the use of a bifunctional organocatalyst in order to activate the γ-hydrogen atoms of the alkylidenepyrazolone nucleophile and the carbonyl group of the trifluoromethylarylketone providing highly functionalized trifluoromethyl alcohols with moderate yields, excellent diastereoselectivity, and moderate to good enantioselectivity. Experiments monitoring the conversion by 1H NMR and the enantiomeric excess by HPLC with the reaction time showed that full conversion …
Organocatalytic Enantioselective Aminoalkylation of 5‐Aminopyrazole Derivatives with Cyclic Imines
2020
The first enantioselective alkylation of 5‐aminopyrazoles is described with good results. The organocatalytic alkylation of 5‐aminopyrazoles have been accomplished using benzoxathiazine 2,2‐dioxides as electrophiles and a bifunctional squaramide organocatalyst.
CCDC 2122953: Experimental Crystal Structure Determination
2021
Related Article: Laura Carceller-Ferrer, Aleix González del Campo, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2022|J.Org.Chem.|87|4538|doi:10.1021/acs.joc.1c02817
CCDC 2024661: Experimental Crystal Structure Determination
2020
Related Article: Laura Carceller-Ferrer, Aleix González del Campo, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2020|Eur.J.Org.Chem.|2020|7450|doi:10.1002/ejoc.202001314