Dataset related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation"

This record contains raw data related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation". Abstract Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal ce…