0000000001312475
AUTHOR
Sandra Trefler
Oxidative stress protection by manganese complexes of tail-tied aza-scorpiand ligands.
The Mn2+ coordination chemistry of double scorpiand ligands in which two polyazacyclophane macrocycles have been connected by pyridine, phenanthroline and bipyridine spacers has been studied by potentiometry, paramagnetic NMR and electrochemistry. All ligands show high stability with Mn2+ and the complexes were formed in a wide pH range. DFT calculations support the structures and coordination geometries derived from the study. A remarkable antioxidant activity was evidenced for these systems by the McCord-Fridovich assay and in Escherichiacoli sodAsodB deficient bacterial cells. The three systems were tested as anti-inflammatory drugs in human macrophages measuring the accumulation of cyto…
Homo- and Heterobinuclear Cu2+ and Zn2+ Complexes of Ditopic Aza Scorpiand Ligands as Superoxide Dismutase Mimics
Two polytopic aza-scorpiand-like ligands, 6-[7-(diaminoethyl)-3,7-diazaheptyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L1) and 6-[6′-[3,6,9-triaza-1-(2,6-pyridina)cyclodecaphan-6-yl]-3-azahexyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L2), have been synthesized. The acid–base behavior and Cu2+, Zn2+, and Cu2+/Zn2+ mixed coordination have been analyzed by potentiometry, cyclic voltammetry, and UV–vis spectroscopy. The resolution of the crystal structures of [Cu2L2Cl2](ClO4)2·1.67H2O (1), [Cu2HL2Br2](ClO4)3·1.5H2O (2), and [CuZnL2Cl2](ClO4)2·1.64H2O (3) shows, in agreement with the solution data, the formation of homobinuclear Cu2+/Cu2+ and heterobinuclear Cu2+/Zn2+ complexes. The m…
CCDC 1507631: Experimental Crystal Structure Determination
Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756
CCDC 1507632: Experimental Crystal Structure Determination
Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756
CCDC 1507630: Experimental Crystal Structure Determination
Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756