0000000001312475

AUTHOR

Sandra Trefler

showing 5 related works from this author

Oxidative stress protection by manganese complexes of tail-tied aza-scorpiand ligands.

2015

The Mn2+ coordination chemistry of double scorpiand ligands in which two polyazacyclophane macrocycles have been connected by pyridine, phenanthroline and bipyridine spacers has been studied by potentiometry, paramagnetic NMR and electrochemistry. All ligands show high stability with Mn2+ and the complexes were formed in a wide pH range. DFT calculations support the structures and coordination geometries derived from the study. A remarkable antioxidant activity was evidenced for these systems by the McCord-Fridovich assay and in Escherichiacoli sodAsodB deficient bacterial cells. The three systems were tested as anti-inflammatory drugs in human macrophages measuring the accumulation of cyto…

AntioxidantStereochemistrymedicine.medical_treatmentPhenanthrolineInorganic chemistrychemistry.chemical_elementManganese010402 general chemistryElectrochemistry01 natural sciencesBiochemistryAntioxidantsCoordination complexInorganic ChemistrySuperoxide dismutasechemistry.chemical_compoundBipyridineBacterial ProteinsCoordination ComplexesCell Line TumorPyridinemedicineEscherichia coliHumanschemistry.chemical_classificationManganesebiology010405 organic chemistryChemistrySuperoxide DismutaseMacrophagesAnti-Inflammatory Agents Non-Steroidal0104 chemical sciencesOxidative Stressbiology.proteinJournal of inorganic biochemistry
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Homo- and Heterobinuclear Cu2+ and Zn2+ Complexes of Ditopic Aza Scorpiand Ligands as Superoxide Dismutase Mimics

2017

Two polytopic aza-scorpiand-like ligands, 6-[7-(diaminoethyl)-3,7-diazaheptyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L1) and 6-[6′-[3,6,9-triaza-1-(2,6-pyridina)cyclodecaphan-6-yl]-3-azahexyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L2), have been synthesized. The acid–base behavior and Cu2+, Zn2+, and Cu2+/Zn2+ mixed coordination have been analyzed by potentiometry, cyclic voltammetry, and UV–vis spectroscopy. The resolution of the crystal structures of [Cu2L2Cl2](ClO4)2·1.67H2O (1), [Cu2HL2Br2](ClO4)3·1.5H2O (2), and [CuZnL2Cl2](ClO4)2·1.64H2O (3) shows, in agreement with the solution data, the formation of homobinuclear Cu2+/Cu2+ and heterobinuclear Cu2+/Zn2+ complexes. The m…

biology010405 organic chemistryChemistryLigandStereochemistryMetal ions in aqueous solutionCrystal structure010402 general chemistry01 natural sciences0104 chemical sciencesInorganic ChemistrySuperoxide dismutaseCrystallographybiology.proteinPhysical and Theoretical ChemistryCyclic voltammetrySpectroscopyStoichiometryInorganic Chemistry
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CCDC 1507631: Experimental Crystal Structure Determination

2017

Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu-3-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)-N-(2-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)ethyl)propylammonium)-dibromo-di-copper(ii) triperchlorate sesquihydrateExperimental 3D Coordinates
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CCDC 1507632: Experimental Crystal Structure Determination

2017

Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu-3-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)-N-(2-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)ethyl)propan-1-amine)-dichloro-copper-zinc diperchlorate hydrateExperimental 3D Coordinates
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CCDC 1507630: Experimental Crystal Structure Determination

2017

Related Article: Lluís Guijarro, Mario Inclán, Javier Pitarch-Jarque, Antonio Doménech-Carbó, Javier U. Chicote, Sandra Trefler, Enrique García-España, Antonio García-España, Begoña Verdejo|2017|Inorg.Chem.|56|13748|doi:10.1021/acs.inorgchem.7b01756

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu-3-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)-N-(2-(36915-tetraazabicyclo[9.3.1]pentadeca-1(15)1113-trien-6-yl)ethyl)propan-1-amine)-dichloro-di-copper diperchlorate hydrateExperimental 3D Coordinates
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