6533b85bfe1ef96bd12bb649
RESEARCH PRODUCT
Oxidative stress protection by manganese complexes of tail-tied aza-scorpiand ligands.
Begoña VerdejoRoberto TejeroAntonio Doménech-carbóJorge González-garcíaAntonio Garcia-españaEnrique CalvoEnrique García-españaSandra TreflerCarolina SerenaConcepción SorianoM. Paz ClaresHermas R. JiménezÁLvaro Martínez-camarenaLaura Briansó-llortsubject
AntioxidantStereochemistrymedicine.medical_treatmentPhenanthrolineInorganic chemistrychemistry.chemical_elementManganese010402 general chemistryElectrochemistry01 natural sciencesBiochemistryAntioxidantsCoordination complexInorganic ChemistrySuperoxide dismutasechemistry.chemical_compoundBipyridineBacterial ProteinsCoordination ComplexesCell Line TumorPyridinemedicineEscherichia coliHumanschemistry.chemical_classificationManganesebiology010405 organic chemistryChemistrySuperoxide DismutaseMacrophagesAnti-Inflammatory Agents Non-Steroidal0104 chemical sciencesOxidative Stressbiology.proteindescription
The Mn2+ coordination chemistry of double scorpiand ligands in which two polyazacyclophane macrocycles have been connected by pyridine, phenanthroline and bipyridine spacers has been studied by potentiometry, paramagnetic NMR and electrochemistry. All ligands show high stability with Mn2+ and the complexes were formed in a wide pH range. DFT calculations support the structures and coordination geometries derived from the study. A remarkable antioxidant activity was evidenced for these systems by the McCord-Fridovich assay and in Escherichiacoli sodAsodB deficient bacterial cells. The three systems were tested as anti-inflammatory drugs in human macrophages measuring the accumulation of cytokines upon lipopolysaccharide (LPS) pro-inflammatory effect. All complexes showed anti-inflammatory effect, being [Mn2L1]4+ the most efficient one.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-08 | Journal of inorganic biochemistry |