0000000001312604
AUTHOR
Philipp J. Kohlpaintner
Selective Formation of 4,4'-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction.
A simple and selective electrochemical synthesis by dehydrogenative coupling of unprotected 2,6- or 2,5-substituted phenols to the desired 4,4'-biphenols is reported. Using electricity as the oxidizing reagent avoids pre-functionalization of the starting materials, since a selective activation of the substrates takes place. Without the necessity for metal-catalysts or the use of stoichiometric reagents it is an economic and environmentally friendly transformation. The elaborated electrochemical protocol leads to a broad variety of the desired 4,4'-biphenols in a very simplified manner compared to classical approaches. This is particular the case for the cross-coupled products.
CCDC 1858697: Experimental Crystal Structure Determination
Related Article: Benedikt Dahms, Philipp J. Kohlpaintner, Anton Wiebe, Rolf Breinbauer, Dieter Schollmeyer, Siegfried R. Waldvogel|2019|Chem.-Eur.J.|25|2713|doi:10.1002/chem.201805737
CCDC 1858698: Experimental Crystal Structure Determination
Related Article: Benedikt Dahms, Philipp J. Kohlpaintner, Anton Wiebe, Rolf Breinbauer, Dieter Schollmeyer, Siegfried R. Waldvogel|2019|Chem.-Eur.J.|25|2713|doi:10.1002/chem.201805737