0000000001313125

AUTHOR

Laura A. Hager

showing 5 related works from this author

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular …

2018

Fluorescent 4-ethylthio-1,8-naphthalimides containing rhodium(I) N-heterocyclic carbene (NHC) and ruthenium (II) NHC fragments were synthesised and evaluated for their antiproliferative effects, cellular uptake and DNA-binding activity. Both types of organometallics triggered ligand dependent efficient cytotoxic effects against tumor cells with the rhodium(I) NHC derivatives causing stronger effects than the ruthenium (II) NHC analogues. Antiproliferative effects could also be observed against several pathogenic Gram-positive bacterial strains, whereas the growth of Gram-negative bacteria was not substantially affected. Cellular uptake was confirmed by atomic absorption spectroscopy as well…

Intercalation (chemistry)Fluorescent DyeLigands01 natural sciencesAntineoplastic Agentchemistry.chemical_compoundNeoplasmsDrug DiscoveryMoietyCell DeathBacterial InfectionsGeneral MedicineIntercalating AgentsNaphthalimideAnti-Bacterial AgentsRutheniumNaphthalimidesSettore CHIM/03 - Chimica Generale E InorganicaHumanStereochemistrychemistry.chemical_elementAntineoplastic AgentsLigandCarbene010402 general chemistryG-quadruplexBacterial InfectionRutheniumRhodiumCell Line TumorAnti-Bacterial AgentOrganometallic CompoundsG-QuadruplexeHumansRhodiumBioorganometallicFluorescent DyesGroup 2 organometallic chemistryCell ProliferationPharmacologyOrganometallic CompoundBacteria010405 organic chemistryLigandOrganic ChemistryIntercalating Agent0104 chemical sciencesG-QuadruplexeschemistryNeoplasmDrug Screening Assays AntitumorCarbene
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Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition.

2019

Quadruplex nucleic acids – DNA/RNA secondary structures formed in guanine rich sequences – proved to have key roles in the biology of cancers and, as such, in recent years they emerged as promising targets for small molecules. Many reports demonstrated that metal complexes can effectively stabilize quadruplex structures, promoting telomerase inhibition, downregulation of the expression of cancer-related genes and ultimately cancer cell death. Although extensively explored as anticancer agents, studies on the ability of ruthenium arene complexes to interact with quadruplex nucleic acids are surprisingly almost unknown. Herein, we report on the synthesis and characterization of four novel Ru(…

GuanineStereochemistryCell Survivalchemistry.chemical_elementAntineoplastic Agents010402 general chemistryG-quadruplexLigands01 natural sciencesRutheniumInorganic Chemistrychemistry.chemical_compoundStructure-Activity RelationshipCoordination ComplexesPyridineTumor Cells CulturedHumansRuthenium Quadruplex G-quadruplex G4 DNA Cancer Metal Complexesheterocyclic compoundsCell ProliferationDose-Response Relationship DrugMolecular Structure010405 organic chemistryLigandRNASmall molecule3. Good health0104 chemical sciencesRutheniumG-QuadruplexeschemistrySettore CHIM/03 - Chimica Generale E InorganicaCalixarenesDrug Screening Assays AntitumorDNADalton transactions (Cambridge, England : 2003)
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CCDC 1870492: Experimental Crystal Structure Determination

2019

Related Article: Laura A. Hager, Stephan Mokesch, Claudia Kieler, Silvia Alonso-de Castro, Dina Baier, Alexander Roller, Wolfgang Kandioller, Bernhard K. Keppler, Walter Berger, Luca Salassa, Alessio Terenzi|2019|Dalton Trans.|48|12040|doi:10.1039/C9DT02078K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(eta6-p-Cymene)-chloro-((13-dioxo-1H-inden-2(3H)-ylidene)((1-naphthylmethyl)amino)methanolato)-ruthenium(ii)Experimental 3D Coordinates
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CCDC 1870494: Experimental Crystal Structure Determination

2019

Related Article: Laura A. Hager, Stephan Mokesch, Claudia Kieler, Silvia Alonso-de Castro, Dina Baier, Alexander Roller, Wolfgang Kandioller, Bernhard K. Keppler, Walter Berger, Luca Salassa, Alessio Terenzi|2019|Dalton Trans.|48|12040|doi:10.1039/C9DT02078K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(eta6-p-Cymene)-chloro-((13-dioxo-1H-inden-2(3H)-ylidene)((2-(1-naphthyl)ethyl)amino)methanolato)-ruthenium(ii) hydrateExperimental 3D Coordinates
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CCDC 1870493: Experimental Crystal Structure Determination

2019

Related Article: Laura A. Hager, Stephan Mokesch, Claudia Kieler, Silvia Alonso-de Castro, Dina Baier, Alexander Roller, Wolfgang Kandioller, Bernhard K. Keppler, Walter Berger, Luca Salassa, Alessio Terenzi|2019|Dalton Trans.|48|12040|doi:10.1039/C9DT02078K

Space GroupCrystallographyCrystal System(eta6-p-Cymene)-((13-dioxo-1H-inden-2(3H)-ylidene)((1-naphthylmethyl)amino)methanolato)-pyridine-ruthenium(ii) hexafluorophosphateCrystal StructureCell ParametersExperimental 3D Coordinates
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