0000000001313267

AUTHOR

G. Dannhardt

showing 5 related works from this author

In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detect…

2001

Objective and Design: The aim of this study was to develop a new, whole-cell test system which is easy to handle and requires a standard equipment for the parallel screening of COX-1 and COX-2 inhibitors.¶Materials: Bovine aortic endothelial cells (BAECs).¶Treatment and methods: Unstimulated bovine aortic coronary endothelial cells (BAECs) were used as a source of COX-1 and BAECs pretreated with ASA (100 μM) and activated with phorbol myristate acetate (PMA) were used as a source of COX-2. The time- and concentration-dependent induction of COX-2 expression in the BAECs was evaluated by a kinetic profile (HPLC analysis) and detected by Western-Blot analysis using polyclonal antibodies agains…

Blotting WesternImmunologyDrug Evaluation PreclinicalAorta ThoracicIn Vitro TechniquesHigh-performance liquid chromatographyLipoxygenaseDiclofenacmedicineAnimalsCyclooxygenase InhibitorsLipoxygenase InhibitorsIC50Chromatography High Pressure LiquidPharmacologyCyclooxygenase 2 InhibitorsbiologyChemistryMolecular biologyIsoenzymesKineticsMeloxicamBiochemistryCyclooxygenase 2Prostaglandin-Endoperoxide SynthasesPolyclonal antibodiesCyclooxygenase 1biology.proteinTetradecanoylphorbol AcetateAceclofenacCattleSpectrophotometry UltravioletEndothelium VascularCyclooxygenasemedicine.drugInflammation Research
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CCDC 269374: Experimental Crystal Structure Determination

2005

Related Article: C.Peifer, R.Selig, K.Kinkel, D.Ott, F.Totzke, C.Schachtele, R.Heidenreich, M.Rocken, D.Schollmeyer, S.Laufer|2008|J.Med.Chem.|51|3814|doi:10.1021/jm8001185

Space GroupCrystallographyCrystal System3-(1H-Indol-3-yl)-4-(345-trimethoxyphenyl)-25-dihydro-1H-pyrrole-25-dioneCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 269812: Experimental Crystal Structure Determination

2005

Related Article: D.Schollmeyer, C.Peifer, G.Dannhardt|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o583|doi:10.1107/S1600536805003478

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersMethyl (4-methoxy-3-(methylsulfonyloxy)benzoyl)formateExperimental 3D Coordinates
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CCDC 269375: Experimental Crystal Structure Determination

2005

Related Article: C.Peifer, D.Schollmeyer, G.Dannhardt|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o724|doi:10.1107/S160053680500485X

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters567-Trimethoxy-23-dihydro-1H8H-benzo(a)pyrrolo(34-c)carbazole-13-dione dimethyl sulfoxide solvateExperimental 3D Coordinates
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CCDC 269813: Experimental Crystal Structure Determination

2005

Related Article: D.Schollmeyer, C.Peifer, G.Dannhardt|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o604|doi:10.1107/S1600536805003685

4-(3-Hydroxy-4-methoxyphenyl)-3-(345-trimethoxyphenyl)-25-dihydro-1H-pyrrole-25-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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