0000000001313607
AUTHOR
Caroline L. Relton
showing 10 related works from this author
Additional file 4 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 4. Assessment of genomic inflation and heterogeneity.
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
2020
AbstractBiological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic …
Additional file 3 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 3. Supplementary Figures - Figures S1-S31.
Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 6. Review history.
Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 5. Colocalization plots.
Additional file 1 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 1. Individual cohort descriptions and acknowledgements.
Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 5. Colocalization plots.
Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 6. Review history.
Additional file 2 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 2. Supplementary Tables -Tables S1-S31.
Additional file 2 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Additional file 2. Supplementary Tables -Tables S1-S31.