0000000001314534
AUTHOR
M. Paula Robalo
Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM46…
Synthesis, characterization and crystal structure of the bimetallic cyano-bridged [(η5-C5H5)(PPh3)2Ru(μ-CN)Ru(PPh3)2(η5-C5H5)][PF6]
Abstract The bimetallic cyano-bridged [(η 5 -C 5 H 5 )(PPh 3 ) 2 Ru(μ-CN)Ru(PPh 3 ) 2 (η 5 -C 5 H 5 )][PF 6 ] ( 1 ) was prepared by reaction of [(η 5 -C 5 H 5 )(PPh 3 ) 2 RuCl] with N , N ′-bis(cyanomethyl)ethylenediamine. The single crystal structure determined by X-ray diffraction showed crystallization on the triclinic P1 space group with a perfect alignment of the cyanide bridges. This accentric crystallization was explored having in view the NLO properties at the macroscopic level, determined by the Kurtz Powder technique. Besides the very low efficiency values for the second harmonic generation, the value obtained for the bimetallic complex 1 showed to be higher than one of the parent…
CCDC 1493775: Experimental Crystal Structure Determination
Related Article: Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente|2018|Eur.J.Med.Chem.|143|503|doi:10.1016/j.ejmech.2017.11.059
CCDC 1535674: Experimental Crystal Structure Determination
Related Article: Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente|2018|Eur.J.Med.Chem.|143|503|doi:10.1016/j.ejmech.2017.11.059