6533b826fe1ef96bd1284954
RESEARCH PRODUCT
Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Anabela SanchesAndreia ValenteAna PretoTiago MoreiraTiago MoreiraRajendhraprasad TatikondaFernando AvecillaLeonor Côrte-realM. Helena GarciaM. Paula RobaloM. Paula RobaloAna Rita BrásAna Rita BrásMatti HaukkaRicardo G. Teixeirasubject
PyridinesApoptosisLigands01 natural sciencesBipyridinechemistry.chemical_compoundDrug DiscoverySelectivityta116Molecular StructureCancro colo-retalChemistryapoptosisCycloparaffinsGeneral Medicine3. Good healthRutheniumsyöpäsolutColorectal NeoplasmsSelectivitymedicine.drugStereochemistryCompostos organometálicoschemistry.chemical_elementAntineoplastic Agentscolorectal cancerTriclinic crystal systemorganometalliyhdisteet010402 general chemistryRutheniumStructure-Activity Relationshipohjelmoitunut solukuolemaCell Line TumorOrganometallic CompoundsmedicineHumansCell ProliferationPharmacologyCisplatinScience & TechnologyDose-Response Relationship DrugApoptose010405 organic chemistryLigandRuthenium methylcyclopentadienylOrganic Chemistryta1182selectivitykompleksiyhdisteetColorectal cancer0104 chemical sciencesperäsuolisyöpäApoptosisCell cultureDrug Screening Assays Antitumorruthenium methylcyclopentadienyldescription
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-12-02 |