0000000001314535
AUTHOR
Fernando Avecilla
Designing binuclear transition metal complexes: a new example of the versatility of N,N′-bis(2-aminobenzyl)-4,13-diaza-18-crown-6
[Abstract] N,N′-Bis(2-aminobenzyl)-4,13-diaza-18-crown-6 (L) is a versatile receptor able to adapt to the coordinative preferences of different metal cation guests. With first-row transition metal ions, L tends to form binuclear complexes but, depending on the nature of the particular metal ion, the structure of the binuclear complex may be very different. Herein we report a study of the structure and magnetic properties of the corresponding nickel(II) and cobalt(II) complexes. The X-ray crystal structure of the nickel complex (1), with formula [Ni2(L)(CH3CN)4](ClO4)4·CH3CN, shows that this compound presents a symmetric coordination environment with L adopting an anti arrangement. Each Ni(I…
Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM46…
Electronic Structure Study of Seven-Coordinate First-Row Transition Metal Complexes Derived from 1,10-Diaza-15-crown-5: A Successful Marriage of Theory with Experiment
A detailed study of the electronic structure of seven-coordinate Mn(II), Co(II), and Ni(II) complexes with the lariat ether N,N'-bis(2-aminobenzyl)-1,10-diaza-15-crown-5 (L(1)) is presented. These complexes represent new examples of structurally characterized seven-coordinate (pentagonal bipyramidal) complexes for the Mn(II), Co(II), and Ni(II) ions. The X-ray crystal structures of the Mn(II) and Co(II) complexes show C(2) symmetries for the [M(L(1))](2+) cations, whereas the structures of the Ni(II) complexes show a more distorted coordination environment. The magnetic properties of the Mn(II) complex display a characteristic Curie law, whereas those of the Co(II) and Ni(II) ions show the …
CCDC 1493775: Experimental Crystal Structure Determination
Related Article: Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente|2018|Eur.J.Med.Chem.|143|503|doi:10.1016/j.ejmech.2017.11.059
CCDC 1535674: Experimental Crystal Structure Determination
Related Article: Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente|2018|Eur.J.Med.Chem.|143|503|doi:10.1016/j.ejmech.2017.11.059