0000000001316392
AUTHOR
Moussa Ali
Coumarin-Phosphine-Based Smart Probes for Tracking Biologically Relevant Metal Complexes: From Theoretical to Biological Investigations
International audience; Ten metal-based complexes and associated ligands have been synthesized and characterized. One of the metal ligands is a coumarin-phosphine derivative, which displays tunable fluorescence properties. The fluorescence is quenched in the case of the free ligand and ruthenium and osmium complexes, whereas it is strong for the gold complexes and phosphonium derivatives. These trends were rationalized by theoretical calculations, which revealed non-radiative channels involving a dark state for the free ligands that is lower in energy than the emissive state and is responsible for the quenching of fluorescence. For the Ru-II and Os-II complexes, other non-radiative channels…
Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a “Smart” Probe Answer!
Gold phosphine complexes, such as auranofin, have been recognized for decades as antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or anti-HIV treatments. However, their mechanisms of action remain unclear. A challenging question is whether the gold phosphine complex is a prodrug that is administered in an inactive precursor form or rather that the gold atom remains attached to the phosphine ligand during treatment. In this study, we present two novel gold complexes, which we compared to auranofin and to their phosphonium analogue. The chosen ligand is a phosphine-based smart probe, whose strong fluorescence depends on the presence of the gold atom. …
CCDC 1420553: Experimental Crystal Structure Determination
Related Article: Lucile Dondaine, Daniel Escudero, Moussa Ali, Philippe Richard, Franck Denat, Ali Bettaieb, Pierre Le Gendre, Catherine Paul, Denis Jacquemin, Christine Goze and Ewen Bodio|2016|Eur.J.Inorg.Chem.||545|doi:10.1002/ejic.201501304
CCDC 1014822: Experimental Crystal Structure Determination
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480
CCDC 1014823: Experimental Crystal Structure Determination
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480
CCDC 1420552: Experimental Crystal Structure Determination
Related Article: Lucile Dondaine, Daniel Escudero, Moussa Ali, Philippe Richard, Franck Denat, Ali Bettaieb, Pierre Le Gendre, Catherine Paul, Denis Jacquemin, Christine Goze and Ewen Bodio|2016|Eur.J.Inorg.Chem.||545|doi:10.1002/ejic.201501304
CCDC 1014821: Experimental Crystal Structure Determination
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480