0000000001318982

AUTHOR

Robert F. Krueger

showing 3 related works from this author

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium:an application of I…

2014

Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia…

DIMENSIONSDISORDERS515 PsychologyeducationPersonality AssessmentGenome-wide association studiesExtraversion PsychologicalNEO-PI5-FACTOR MODELGeneticsHumansGenetics(clinical)Ecology Evolution Behavior and SystematicsOriginal ResearchNeuroticismMeasurementNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Models StatisticalOther Research Radboud Institute for Health Sciences [Radboudumc 0]GENOME-WIDE METAANALYSISTEMPERAMENTASSOCIATIONAnxiety Disorders3142 Public health care science environmental and occupational healthMeta-analysisPhenotypeMEASUREMENT INVARIANCECLONINGERSUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]REPLICATIONDevelopmental PsychopathologyItem-Response TheoryConsortiumGenome-Wide Association StudyPersonality
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G×E Interaction Influences Trajectories of Hand Grip Strength.

2016

Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex …

AdultMaleLongitudinal studyAgingTwinsTwins Monozygotic/geneticsBiologyEnvironmentArticle03 medical and health sciencesGrip strength0302 clinical medicineApolipoproteins ECognitive changeHand strengthGeneticsHumans030212 general & internal medicineHand Strength/physiologyAging/psychologyLongitudinal StudiesGene–environment interactionGenetics (clinical)Ecology Evolution Behavior and SystematicsAgedAged 80 and overHand StrengthAge FactorsGrowth curve (biology)Twins MonozygoticMiddle AgedTwin studyGene-environment interactionkaksosetGrip strengthFemaleGene-Environment InteractionApolipoproteins E/genetics030217 neurology & neurosurgeryAPOEDemographyBehavior genetics
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Midlife in the United States (MIDUS 2), 2004-2006

2007

In 1995-1996, the MacArthur Midlife Research Network carried out a national survey of 7,108 Americans aged 25 to 74 (MIDLIFE IN THE UNITED STATES (MIDUS), 1995-1996 [ICPSR 2760]). The purpose of the study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. The study was innovative for its broad scientific scope, its diverse samples (which included twins and the siblings of main sample respondents), and its creative use of in-depth assessments in key areas (e.g., daily stress and cognitive functioning). A description of the study and findings from it are available at http://www.midus.wisc.edu. Wi…

midlifeadultspsychological wellbeinghealth statuslifestyleswork attitudesrelationshipssocial indicatorstwinslife satisfactionmental healthsiblings
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