6533b823fe1ef96bd127f1db
RESEARCH PRODUCT
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium:an application of Item Response Theory
Stéphanie M. Van Den BergMarleen H. M. De MoorMatt McgueErik PetterssonAntonio TerraccianoKarin J. H. VerweijNajaf AminJaime DerringerTõnu EskoGerard Van GrootheestNarelle K. HansellJennifer HuffmanBettina KonteJari LahtiMichelle LucianoLindsay K. MattesonAlexander ViktorinJasper WoudaArpana AgrawalJüri AllikLaura BierutUlla BromsHarry CampbellGeorge Davey SmithJohan G. ErikssonLuigi FerrucciBarbera FrankeJean-paul FoxEco J. C. De GeusIna GieglingAlan J. GowRichard GruczaAnnette M. HartmannAndrew C. HeathKauko HeikkiläWilliam G. IaconoJoost JanzingMarkus JokelaLambertus KiemeneyTerho LehtimäkiPamela A. F. MaddenPatrik K. E. MagnussonKate NorthstoneTeresa NutileKlaasjan G. OuwensAarno PalotieAlison PattieAnu-katriina PesonenOzren PolasekLea PulkkinenLaura Pulkki-råbackOlli T. RaitakariAnu RealoRichard J. RoseDaniela RuggieroIlkka SeppäläWendy S. SlutskeDavid C. SmythRossella SoriceJohn M. StarrAngelina R. SutinToshiko TanakaJosine VerhagenSita VermeulenEero VuoksimaaElisabeth WidenGonneke WillemsenMargaret J. WrightLina ZgagaDan RujescuAndres MetspaluJames F. WilsonMarina CiulloCaroline HaywardIgor RudanIan J. DearyKatri RäikkönenAlejandro Arias VasquezPaul T. CostaLiisa Keltikangas-järvinenCornelia M. Van DuijnBrenda W. J. H. PenninxRobert F. KruegerDavid M. EvansJaakko KaprioNancy L. PedersenNicholas G. MartinDorret I. Boomsmasubject
DIMENSIONSDISORDERS515 PsychologyeducationPersonality AssessmentGenome-wide association studiesExtraversion PsychologicalNEO-PI5-FACTOR MODELGeneticsHumansGenetics(clinical)Ecology Evolution Behavior and SystematicsOriginal ResearchNeuroticismMeasurementNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Models StatisticalOther Research Radboud Institute for Health Sciences [Radboudumc 0]GENOME-WIDE METAANALYSISTEMPERAMENTASSOCIATIONAnxiety Disorders3142 Public health care science environmental and occupational healthMeta-analysisPhenotypeMEASUREMENT INVARIANCECLONINGERSUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]REPLICATIONDevelopmental PsychopathologyItem-Response TheoryConsortiumGenome-Wide Association StudyPersonalitydescription
Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Electronic supplementary material The online version of this article (doi:10.1007/s10519-014-9654-x) contains supplementary material, which is available to authorized users.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-07-01 |