0000000001320555

AUTHOR

Blessing O. Umeokoli

showing 4 related works from this author

A new depsidone derivative from mangrove sediment derived fungus

2018

A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against …

Magnetic Resonance SpectroscopyStereochemistryPlant ScienceFungus01 natural sciencesBiochemistryDepsidesAnalytical Chemistrychemistry.chemical_compoundLactonesMiceAscomycotaAnimalsIC50biology010405 organic chemistryChemistryDepsidoneOrganic ChemistryBiological activitybiology.organism_classification0104 chemical sciences010404 medicinal & biomolecular chemistryCell cultureWetlandsMangroveDerivative (chemistry)Lasiodiplodia theobromaeNatural product research
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A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae

2018

A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against …

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CCDC 1946592: Experimental Crystal Structure Determination

2020

Related Article: Haiqian Yu, Simon-Patrick Höfert, Mariam Moussa, Christoph Janiak, Werner E.G. Müller, Blessing O. Umeokoli, Haofu Dai, Zhen Liu, Peter Proksch|2019|Tetrahedron Lett.|60|151325|doi:10.1016/j.tetlet.2019.151325

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatesphomopone A
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CCDC 1517632: Experimental Crystal Structure Determination

2017

Related Article: Hao Wang, Blessing O. Umeokoli, Peter Eze, Christian Heering, Christoph Janiak, Werner E.G. Müller, Raha S. Orfali, Rudolf Hartmann, Haofu Dai, Wenhan Lin, Zhen Liu, Peter Proksch|2017|Tetrahedron Lett.|58|1702|doi:10.1016/j.tetlet.2017.03.052

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters8-hydroxy-3a911b-trimethyl-9-vinyl-3a455a89101111b11c-decahydro-3H-benzo[c]furo[34-f]chromene-17-dioneExperimental 3D Coordinates
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