Author: Rani Rajan

0000000001320928

AUTHOR

Rani Rajan

An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides

A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes or alkylidene cyclopentenes in good to excellent yields. By taking advantage of multiple points of functionalization in the synthesized trans-3-phenyl-4-hydrazino-cyclopentene, we have synthesized the antidepressant Cypenamine (trans-2-phenylcyclopentylamine).

research product

CCDC 782677: Experimental Crystal Structure Determination

Related Article: Nayana Joseph,Rani Rajan,Jubi John,N. V. Devika,S. Sarath Chand,E. Suresh,Petri M. Pihko,K. V. Radhakrishnan|2013|RSC Advances|3|7751|doi:10.1039/c3ra41504j

research product

PEPhysical Sciences and Engineering
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