6533b828fe1ef96bd1288ef7
RESEARCH PRODUCT
An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides
Kokkuvayil Vasu RadhakrishnanRani RajanNayana JosephN. V. DevikaJubi JohnShyam ChandPetri M. PihkoEringathodi Sureshsubject
Bicyclic moleculeChemistryGeneral Chemical EngineeringArylchemistry.chemical_elementHalideGeneral ChemistryRing (chemistry)Medicinal chemistryCatalysischemistry.chemical_compoundReagentOrganic chemistryStereoselectivityta116Palladiumdescription
A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes or alkylidene cyclopentenes in good to excellent yields. By taking advantage of multiple points of functionalization in the synthesized trans-3-phenyl-4-hydrazino-cyclopentene, we have synthesized the antidepressant Cypenamine (trans-2-phenylcyclopentylamine).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | RSC Advances |