Author: Daniel Esperilla

0000000001323255

AUTHOR

Daniel Esperilla

showing 2 related works from this author

A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine

2022

A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtained in moderate to excellent yields and with high enantioselectivities. The stereochemical outcome of the reaction has been explained by DFT calculations.

CatàlisiOrganic ChemistryPhysical and Theoretical ChemistryQuímica orgànicaBiochemistryOrganicbiomolecular chemistry

researchProduct

CCDC 2190657: Experimental Crystal Structure Determination

2022

Related Article: Amparo Sanz-Marco, Daniel Esperilla, Marc Montesinos-Magraner, Carlos Vila, M. Carmen Muñoz, José R. Pedro, Gonzalo Blay|2022|Org.Biomol.Chem.|21|345|doi:10.1039/D2OB01763F

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-(33-difluoro-2-hydroxy-4-oxo-4-(thiophen-2-yl)butan-2-yl)pyridine N-oxideExperimental 3D Coordinates

researchProduct

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