0000000001325636
AUTHOR
Alexandra Langlais
Outcomes of Patients With Advanced NSCLC From the Intergroupe Francophone de Cancérologie Thoracique Biomarkers France Study by KRAS Mutation Subtypes
Abstract Introduction KRAS mutations are detected in 20% to 30% of NSCLC. However, KRAS mutation subtypes may differently influence the outcome of patients with advanced NSCLC. Methods In the Biomarkers France study, 4894 KRAS mutations (26.2%) were detected in 4634 patients from the 17,664 enrolled patients with NSCLC. Survival and treatment data on noncurative stage III to IV NSCLC were available for 901 patients. First- and second-line treatment effects on progression-free survival and overall survival were analyzed according to the KRAS mutations subtype. Results Over 95% of patients with KRAS mutation were smokers or former smokers who were white (99.5%), presenting with adenocarcinoma…
Introduction to the concept of ecological solidarity and its challenges
This long introduction will be done by two speakers (Maylis Desrousseaux and Alexandra Langlais) The ecological solidarity is an environmental concept coming from both the ecological sciences and the human sciences. Its definition is recent, however, it is inspired of the concept and juridical principle “solidarity” in France. The latter benefit of a large audience among research, public policies and civil societies. Thus, by drawing a strong link between the environment and humans, the ecological solidarity appears as a lever to achieve the Planetary well-being. In the view of the planetary well- being, we will explore three dimensions of the concept of ecological solidarity: The first one…
Ecological solidarity as an avatar of Animist spirituality
Animism is a worldview of Siberian origin that diffused out in the Americas thousands of years ago. Shamanism is its main spiritual expression, but it is also perceptible in hunting and gathering practices. It relies on the idea that human and other living beings are societies related to each other, among which cooperation, reciprocity, but also wars and retaliations (e.g. because of overkilling) can happen. Animist peoples understand the world not as a hierarchy, but as constituted by different beings, and the shaman plays the role of an intermediary between these entities, thanks to his power of transformation and mental trips among the underworld of master-spirits. Thus, animist societie…