0000000001327238
AUTHOR
G Olsson
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through w…
Advances in Wastewater Treatment
Advances in Wastewater Treatment presents a compendium of the key topics surrounding wastewater treatment, assembled by looking at the future technologies, and provides future perspectives in wastewater treatment and modelling. It covers the fundamentals and innovative wastewater treatment processes (such as membrane bioreactors and granular process). Furthermore, it focuses attention on mathematical modelling aspects in the field of wastewater treatments by highlighting the key role of models in process design, operation and control.