0000000001331092
AUTHOR
Stefano Bianchi
Role of the hospital pharmacist in an Italian antimicrobial stewardship programme
The inappropriate use of antimicrobial agents is contributing to an increasing phenomenon of bacterial resistance. For this reason, there is a growing interest in ‘antimicrobial stewardship’, a series of coordinated and multidisciplinary interventions aimed to promote the safe and appropriate use of antimicrobials in which the pharmacist’s contribution is necessary for the optimal choice of drug, dose, duration of therapy and the implementation of cost containment strategies. AIM OF THE STUDY: We wanted to create a reference model and a specific training manual on antibiotic stewardship to introduce the role of the department pharmacist with specific infection disease skills in the Italian …
Accretion in strong field gravity with eXTP
In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.
Testing warm Comptonization models for the origin of the soft X-ray excess in AGNs
The X-ray spectra of many active galactic nuclei (AGN) show a soft X-ray excess below 1-2 keV on top of the extrapolated high- energy power law. The origin of this component is uncertain. It could be a signature of relativistically blurred, ionized reflection, or the high-energy tail of thermal Comptonization in a warm (kT $\sim$ 1 keV), optically thick ($\tau\simeq$ 10-20) corona producing the optical/UV to soft X-ray emission. The purpose of the present paper is to test the warm corona model on a statistically significant sample of unabsorbed, radio-quiet AGN with XMM-newton archival data, providing simultaneous optical/UV and X-ray coverage. The sample has 22 objects and 100 observations…
The evolution of European Medicines Agency drug approval: the adaptive licensing: Table 1
In March 2014, the European Medicines Agency (EMA) launched a pilot project of ‘adaptive licensing’ to speed up access to drugs in development, in order to respond to unmet medical needs. The project will involve parallel scientific advice from the regulatory agency, pharmaceutical industry, the companies Health Technology Assessment (HTAs) bodies, organisations studying guidelines on clinical treatment and patient associations. The traditional process of drug authorisation is divided into several parts, involving in vitro studies and in vivo studies in animals (preclinical studies), as well as phase 1–3 randomised controlled trials conducted in humans over a predefined period. When authori…
The Large Observatory For x-ray Timing
The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m 2 effective area, 2-30 keV, 240 eV spectral resolution, 1 deg collimated field of view) and a WideFi…
Astrophysics with the Laser Interferometer Space Antenna
Full list of authors: Amaro-Seoane, Pau; Andrews, Jeff; Sedda, Manuel Arca; Askar, Abbas.; Baghi, Quentin; Balasov, Razvan; Bartos, Imre; Bavera, Simone S.; Bellovary, Jillian; Berry, Christopher P. L.; Berti, Emanuele; Bianchi, Stefano; Blecha, Laura; Blondin, Stephane; Bogdanovic, Tamara; Boissier, Samuel; Bonetti, Matteo; Bonoli, Silvia; Bortolas, Elisa; Breivik, Katelyn; Capelo, Pedro R.; Caramete, Laurentiu; Cattorini, Federico; Charisi, Maria; Chaty, Sylvain; Chen, Xian; Chruslinska, Martyna; Chua, Alvin J. K.; Church, Ross; Colpi, Monica; D'Orazio, Daniel; Danielski, Camilla; Davies, Melvyn B.; Dayal, Pratika; De Rosa, Alessandra; Derdzinski, Andrea; Destounis, Kyriakos; Dotti, Massi…
Looking through the photoionisation wake: Vela X−1 at φorb ≈ 0.75 with Chandra/HETG
Context. The supergiant X-ray binary Vela X−1 represents one of the best astrophysical sources to investigate the wind environment of an O/B star irradiated by an accreting neutron star. Previous studies and hydrodynamic simulations of the system have revealed a clumpy environment and the presence of two wakes: an accretion wake surrounding the compact object and a photoionisation wake trailing it along the orbit. Aims. Our goal is to conduct, for the first time, high-resolution spectroscopy on Chandra/HETGS data at the orbital phase φorb ≈ 0.75, when the line of sight is crossing the photoionisation wake. We aim to conduct plasma diagnostics, inferring the structure and the geometry of the…
Observatory science with eXTP
Disponible preprint en: arXiv:1812.04023v1 [astro-ph.HE] [v1] Mon, 10 Dec 2018 19:00:52 UTC (4,376 KB)
Wind-luminosity evolution in NLS1 AGN 1H 0707−495
Ultra-fast outflows (UFOs) have been detected in the high-quality X-ray spectra of a number of active galactic nuclei (AGN) with fairly high accretion rates and are thought to significantly contribute to the AGN feedback. After a decade of dedicated study, their launching mechanisms and structure are still not well understood, but variability techniques may provide useful constraints. In this work, therefore, we perform a flux-resolved X-ray spectroscopy on a highly accreting and variable NLS1 AGN, 1H 0707-495, using all archival XMM-Newton observations to study the structure of the UFO. We find that the wind spectral lines weaken at higher luminosities, most likely due to an increasing ion…
30+ anni di aziendalisti in Laguna. Gli studi manageriali a Venezia
La ricorrenza del trentennale di ALEA, la storica associazione dei laureati in economia aziendale di Ca’ Foscari, apre a una riflessione corale sullo sviluppo degli studi manageriali a Venezia. Primo in Italia assieme alla Bocconi, il corso di laurea in economia aziendale dell’Ateneo veneziano ha formato generazioni di manager, imprenditori e specialisti di caratura internazionale. Scritto assieme a diversi docenti e laureati eccellenti che hanno animato Ca’ Bembo, sede storica del dipartimento, il presente volume indaga l’evoluzione delle discipline aziendali in Laguna, oltre a restituire significative esperienze dei professionisti del management usciti da Ca’ Foscari.