0000000001331313

AUTHOR

Adriana Castro-zavala

showing 3 related works from this author

Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

2020

The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early s…

Reflex StartleStartle responseAnhedoniaPhysiologySelf AdministrationWeaningReinforcing effectsMiceBehavioral NeuroscienceAnimal modelCocaineDopamine Uptake InhibitorsMaternal separation with early weaningFemale micemedicineAnimalsPrepulse inhibitionMotivationmedicine.diagnostic_testPrepulse Inhibitionbusiness.industryMaternal Deprivationmedicine.diseaseAnhedonia-like behavioursConditioned place preferenceSubstance abuseDisease Models AnimalLocomotor sensitizationConditioning OperantBiomarker (medicine)FemalePassive avoidancebusinessBehavioural Brain Research
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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

2019

The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (RSD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 min before each episode of RSD. Three weeks after the last defeat, the effects of cocaine on the conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigms were evaluated. The influence of OXT on the levels of BDNF in the prefrontal cortex (PFC), striatum an…

Male0301 basic medicinemedicine.medical_specialtyConditioning ClassicalPrefrontal CortexHippocampusSelf AdministrationStriatumAnxietyOxytocinHippocampusSocial defeatMice03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineCocaineRewardSocial defeatInternal medicinemedicineAnimalsPrefrontal cortexPharmacologybusiness.industryBrain-Derived Neurotrophic FactorSelf-administrationExtinction (psychology)Conditioned place preferenceCorpus StriatumConditioned place preferenceDisease Models AnimalBDNF030104 developmental biologyEndocrinologyOxytocinConditioning OperantSelf-administrationbusinessReinforcement PsychologyStress Psychologicalhormones hormone substitutes and hormone antagonists030217 neurology & neurosurgerymedicine.drugNeuropharmacology
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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

2018

The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in the stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (SD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 minutes before each episode of SD. Three weeks after the last defeat, the effects of cocaine on conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigm were evaluated. Our results confirm that raising the levels of OXT during social defeat stress can bl…

UNESCO::PSICOLOGÍAhormones hormone substitutes and hormone antagonists
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